Ensembl 2020.
Algorithms
Animals
Computational Biology
/ methods
Computer Graphics
Databases, Genetic
Databases, Protein
Epigenome
Genetic Variation
Genome-Wide Association Study
Genomics
Histones
/ metabolism
Humans
Imaging, Three-Dimensional
Internet
Ligands
Molecular Sequence Annotation
Search Engine
Software
Species Specificity
Transcriptome
User-Computer Interface
Web Browser
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
08 01 2020
08 01 2020
Historique:
accepted:
10
10
2019
revised:
09
10
2019
received:
23
09
2019
pubmed:
7
11
2019
medline:
28
5
2020
entrez:
7
11
2019
Statut:
ppublish
Résumé
The Ensembl (https://www.ensembl.org) is a system for generating and distributing genome annotation such as genes, variation, regulation and comparative genomics across the vertebrate subphylum and key model organisms. The Ensembl annotation pipeline is capable of integrating experimental and reference data from multiple providers into a single integrated resource. Here, we present 94 newly annotated and re-annotated genomes, bringing the total number of genomes offered by Ensembl to 227. This represents the single largest expansion of the resource since its inception. We also detail our continued efforts to improve human annotation, developments in our epigenome analysis and display, a new tool for imputing causal genes from genome-wide association studies and visualisation of variation within a 3D protein model. Finally, we present information on our new website. Both software and data are made available without restriction via our website, online tools platform and programmatic interfaces (available under an Apache 2.0 license) and data updates made available four times a year.
Identifiants
pubmed: 31691826
pii: 5613682
doi: 10.1093/nar/gkz966
pmc: PMC7145704
doi:
Substances chimiques
Histones
0
Ligands
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
D682-D688Subventions
Organisme : Wellcome Trust
ID : 201535/Z/16/Z
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U41 HG007234
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG007823
Pays : United States
Organisme : Wellcome Trust
ID : WT108749/Z/15/Z
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.
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