The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences.
Alcohol Consequences
Alcohol Quantity and Frequency
Family History of Alcohol Use Disorder
Impulsivity-Related Traits
Journal
Alcoholism, clinical and experimental research
ISSN: 1530-0277
Titre abrégé: Alcohol Clin Exp Res
Pays: England
ID NLM: 7707242
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
23
07
2019
accepted:
29
10
2019
pubmed:
7
11
2019
medline:
7
2
2021
entrez:
7
11
2019
Statut:
ppublish
Résumé
Extensive research indicates that having a positive family history of alcohol use disorder (FHP) and impulsivity are 2 risk factors for problem drinking. To our knowledge, no study has investigated which facets of impulsivity interact with family history to increase risk for problem drinking. The goal of this study was to: (i) examine whether FHP individuals with higher levels of impulsivity are more likely to engage in problematic drinking, and (ii) identify which facets of impulsivity interact with FHP to increase risk for problems. The data consisted of a combined sample of 757 participants (50% female, 73% White, mean age = 32.85, SD = 11.31) drawn from the Transdisciplinary Tobacco Use Research Center and the Center for the Translational Neuroscience of Alcohol. Analyses of covariance and cumulative logistic regression models investigated the association of family history and impulsivity-related traits with drinking quantity, frequency, and alcohol-related problems. Models were adjusted for age, sex, race, ethnic group, education level, and data source. Significant interactions between impulsivity and family history were found for measures of alcohol-related problems. Specifically, there was a stronger positive association of Barratt Impulsiveness Scale (BIS) poor self-regulation with interpersonal, F(1, 504) = 6.27, p = 0.01, and impulse control alcohol-related problems, F(1, 504) = 6.00, p = 0.01, among FHP compared to FHN individuals. Main effects of family history and impulsivity on alcohol quantity and frequency of use and problems were also found. These findings suggest that having both a family history of AUD and high BIS poor self-regulation is more strongly associated with alcohol-related consequences in the interpersonal and impulse control domains. Given the heterogeneity of impulsivity, these findings highlight the need for additional research to examine which facets of impulsivity are associated with which alcohol outcomes to narrow phenotypic risk for alcohol misuse.
Sections du résumé
BACKGROUND
Extensive research indicates that having a positive family history of alcohol use disorder (FHP) and impulsivity are 2 risk factors for problem drinking. To our knowledge, no study has investigated which facets of impulsivity interact with family history to increase risk for problem drinking. The goal of this study was to: (i) examine whether FHP individuals with higher levels of impulsivity are more likely to engage in problematic drinking, and (ii) identify which facets of impulsivity interact with FHP to increase risk for problems.
METHODS
The data consisted of a combined sample of 757 participants (50% female, 73% White, mean age = 32.85, SD = 11.31) drawn from the Transdisciplinary Tobacco Use Research Center and the Center for the Translational Neuroscience of Alcohol. Analyses of covariance and cumulative logistic regression models investigated the association of family history and impulsivity-related traits with drinking quantity, frequency, and alcohol-related problems. Models were adjusted for age, sex, race, ethnic group, education level, and data source.
RESULTS
Significant interactions between impulsivity and family history were found for measures of alcohol-related problems. Specifically, there was a stronger positive association of Barratt Impulsiveness Scale (BIS) poor self-regulation with interpersonal, F(1, 504) = 6.27, p = 0.01, and impulse control alcohol-related problems, F(1, 504) = 6.00, p = 0.01, among FHP compared to FHN individuals. Main effects of family history and impulsivity on alcohol quantity and frequency of use and problems were also found.
CONCLUSIONS
These findings suggest that having both a family history of AUD and high BIS poor self-regulation is more strongly associated with alcohol-related consequences in the interpersonal and impulse control domains. Given the heterogeneity of impulsivity, these findings highlight the need for additional research to examine which facets of impulsivity are associated with which alcohol outcomes to narrow phenotypic risk for alcohol misuse.
Identifiants
pubmed: 31693193
doi: 10.1111/acer.14230
pmc: PMC6981005
mid: NIHMS1058311
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
159-167Subventions
Organisme : NIAAA NIH HHS
ID : P50 AA015632
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA019426
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIDA NIH HHS
ID : R25 DA035163
Pays : United States
Organisme : NIAAA NIH HHS
ID : P50 AA012870
Pays : United States
Informations de copyright
Copyright © 2019 by the Research Society on Alcoholism.
Références
Nat Commun. 2019 Apr 2;10(1):1499
pubmed: 30940813
Addict Behav. 2007 Sep;32(9):1852-62
pubmed: 17241748
J Psychiatr Res. 2016 Sep;80:52-58
pubmed: 27295121
J Stud Alcohol. 1985 Jul;46(4):273-8
pubmed: 4033126
J Stud Alcohol. 1979;40(1):89-116
pubmed: 376949
J Abnorm Psychol. 1998 Nov;107(4):616-28
pubmed: 9830249
Alcohol Clin Exp Res. 2010 Aug;34(8):1400-8
pubmed: 20491737
Behav Genet. 2011 Jul;41(4):459-75
pubmed: 21153693
J Stud Alcohol. 1998 Sep;59(5):533-43
pubmed: 9718105
Am J Psychiatry. 2017 Nov 1;174(11):1034-1035
pubmed: 29088935
Addict Biol. 2010 Apr;15(2):217-26
pubmed: 20148781
Psychol Bull. 2014 Mar;140(2):374-408
pubmed: 24099400
Addict Behav. 1989;14(5):537-43
pubmed: 2589132
J Abnorm Psychol. 1991 Nov;100(4):427-48
pubmed: 1757657
J Clin Psychiatry. 2013 Aug;74(8):795-801
pubmed: 24021496
Psychol Assess. 2015 Dec;27(4):1129-46
pubmed: 25822833
J Adolesc. 2016 Apr;48:18-35
pubmed: 26871952
Psychol Assess. 2014 Sep;26(3):1003-20
pubmed: 24885848
J Stud Alcohol. 1985 May;46(3):259-61
pubmed: 4010305
Alcohol Clin Exp Res. 2011 Jul;35(7):1315-20
pubmed: 21676003
J Nerv Ment Dis. 1981 Jul;169(7):456-8
pubmed: 7241111
Addict Behav. 2018 Dec;87:251-259
pubmed: 30096656
J Pers. 2004 Apr;72(2):271-324
pubmed: 15016066
J Consult Clin Psychol. 1987 Jun;55(3):411-7
pubmed: 3597957
Addict Behav. 2012 Jul;37(7):747-75
pubmed: 22445418
J Abnorm Psychol. 2002 Aug;111(3):411-24
pubmed: 12150417
Am J Psychiatry. 1995 Sep;152(9):1322-8
pubmed: 7653688
Alcohol Clin Exp Res. 2010 Aug;34(8):1303-5
pubmed: 20491735
Addict Behav. 2011 Oct;36(10):959-64
pubmed: 21665369
Psychol Med. 2016 Apr;46(5):1091-102
pubmed: 26671289
Clin Psychol Rev. 2013 Jun;33(4):574-92
pubmed: 23563081
Alcohol Clin Exp Res. 2019 Oct;43(10):2100-2110
pubmed: 31373688
J Abnorm Psychol. 2002 Feb;111(1):124-33
pubmed: 11871377
J Clin Psychol. 1995 Nov;51(6):768-74
pubmed: 8778124
J Child Psychol Psychiatry. 2017 Apr;58(4):361-383
pubmed: 28035675
Neurosci Biobehav Rev. 2019 Nov;106:202-216
pubmed: 30343823
Alcohol Clin Exp Res. 2008 Aug;32(8):1451-8
pubmed: 18564105
Alcohol Clin Exp Res. 2013 Sep;37(9):1441-50
pubmed: 23578176
J Abnorm Psychol. 2004 Nov;113(4):483-98
pubmed: 15535782