Genomic Epidemiology of Major Extraintestinal Pathogenic
antimicrobial resistance
extraintestinal pathogenic Escherichia coli
food safety
molecular epidemiology
urinary tract infections
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
06
08
2019
accepted:
04
10
2019
entrez:
8
11
2019
pubmed:
7
11
2019
medline:
7
11
2019
Statut:
epublish
Résumé
A few extraintestinal pathogenic A total of 385 women with UTI caused by ST131, ST69, ST73, ST127, and ST95 were responsible for 54% of all UTIs. Seven UTI clusters were identified, but genomes from the ST95, ST127, and ST420 clusters exhibited as few as 3 single nucleotide variations across the entire genome, suggesting recent acquisition. Furthermore, we identified a cluster of UTIs caused by 6 genetically-related ST1193 isolates carrying mutations in Reservoirs may aid in the dissemination of pandemic ExPEC lineages in the community. Identifying ExPEC reservoirs may help prevent future emergence and dissemination of high-risk lineages within the community setting.
Sections du résumé
BACKGROUND
BACKGROUND
A few extraintestinal pathogenic
METHODS
METHODS
A total of 385 women with UTI caused by
RESULTS
RESULTS
ST131, ST69, ST73, ST127, and ST95 were responsible for 54% of all UTIs. Seven UTI clusters were identified, but genomes from the ST95, ST127, and ST420 clusters exhibited as few as 3 single nucleotide variations across the entire genome, suggesting recent acquisition. Furthermore, we identified a cluster of UTIs caused by 6 genetically-related ST1193 isolates carrying mutations in
CONCLUSIONS
CONCLUSIONS
Reservoirs may aid in the dissemination of pandemic ExPEC lineages in the community. Identifying ExPEC reservoirs may help prevent future emergence and dissemination of high-risk lineages within the community setting.
Identifiants
pubmed: 31696141
doi: 10.1093/ofid/ofz431
pii: ofz431
pmc: PMC6824535
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofz431Informations de copyright
© The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
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