Metabolic Framework for the Improvement of Autism Spectrum Disorders by a Modified Ketogenic Diet: A Pilot Study.
autism
ketogenic diet
metabolic shift
metabolomics
trace elements
Journal
Journal of proteome research
ISSN: 1535-3907
Titre abrégé: J Proteome Res
Pays: United States
ID NLM: 101128775
Informations de publication
Date de publication:
03 01 2020
03 01 2020
Historique:
pubmed:
8
11
2019
medline:
17
4
2021
entrez:
8
11
2019
Statut:
ppublish
Résumé
The ketogenic diet (KD) can improve the core features of autism spectrum disorders (ASD) in some children, but the effects on the overall metabolism remain unclear. This pilot study investigated the behavioral parameters in relation to blood metabolites and trace elements in a cohort of 10 typically developed controls (TC) and 17 children with ASD at baseline and following 3 months of treatment with a modified KD regimen. A nontargeted, multiplatform metabolomic approach was employed, including gas chromatography-mass spectrometry,
Identifiants
pubmed: 31696714
doi: 10.1021/acs.jproteome.9b00581
doi:
Substances chimiques
Isotopes
0
Selenium-77
0
Selenium-78
0
Trace Elements
0
Selenium
H6241UJ22B
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM