Solving the Mysteries of Dementia: FTD Mutant Tau Impairs Structural Axon Initial Segment Plasticity.

Axon Initial Segment Frontotemporal Dementia Homeostasis Humans Tauopathies tau Proteins

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
06 11 2019
Historique:
entrez: 8 11 2019
pubmed: 8 11 2019
medline: 17 3 2020
Statut: ppublish

Résumé

Accumulation of abnormal Tau is a characteristic feature of a number of neurodegenerative disorders, called tauopathies. What is the reason for Tau toxicity in neuronal cells? In this issue of Neuron, Sohn et al. (2019) found that FTD mutant Tau-V337M blocks axon initial segment (AIS) plasticity, causing neuronal hyperexcitability.

Identifiants

DOI: 10.1016/j.neuron.2019.10.021 PMID: 31697915
pubmed: 31697915
pii: S0896-6273(19)30895-5
doi: 10.1016/j.neuron.2019.10.021
pii:
doi:

Substances chimiques

tau Proteins 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

429-430

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Joanna Lipka (J)

Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA.

Casper C Hoogenraad (CC)

Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address: hoogenraad.casper@gene.com.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Segment initial de l'axone › Solving the Mysteries of Dementia: FTD Mutant...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Dégénérescence lobaire frontotemporale › Démence frontotemporale › Solving the Mysteries of Dementia: FTD Mutant...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Solving the Mysteries of Dementia: FTD Mutant...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Solving the Mysteries of Dementia: FTD Mutant...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Tauopathies › Solving the Mysteries of Dementia: FTD Mutant...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines associées aux microtubules › Protéines tau › Solving the Mysteries of Dementia: FTD Mutant...