Flumazenil-insensitive benzodiazepine binding sites in GABA
Animals
Azides
/ pharmacology
Benzodiazepines
/ metabolism
Bicuculline
/ pharmacology
Binding Sites
/ drug effects
Clonazepam
/ pharmacology
Dose-Response Relationship, Drug
Female
Flumazenil
/ pharmacology
GABA Antagonists
/ pharmacology
GABA Modulators
/ pharmacology
Larva
Male
Motor Activity
/ drug effects
Receptors, GABA-A
/ drug effects
Zebrafish
Benzodiazepine
GABA(A) receptor
Immobility
Nonclassical binding site
Zebrafish
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
15 Dec 2019
15 Dec 2019
Historique:
received:
01
08
2019
revised:
16
10
2019
accepted:
28
10
2019
pubmed:
8
11
2019
medline:
24
12
2019
entrez:
8
11
2019
Statut:
ppublish
Résumé
Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABA Zebrafish larvae were treated with a series of BZDs alone or combined with flumazenil, bicuculline (a non-selective GABA Diazepam-induced hypolocomotion (sedation-like state) at low doses (10 and 20 mg L These results provide direct in vivo evidence for non-classical BZD-binding sites, which may be located at the second transmembrane domain of GABA
Identifiants
pubmed: 31697950
pii: S0024-3205(19)30960-9
doi: 10.1016/j.lfs.2019.117033
pii:
doi:
Substances chimiques
Azides
0
GABA Antagonists
0
GABA Modulators
0
Receptors, GABA-A
0
Benzodiazepines
12794-10-4
Flumazenil
40P7XK9392
Clonazepam
5PE9FDE8GB
Ro 15-4513
91917-65-6
Bicuculline
Y37615DVKC
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
117033Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.