Preventing dysbiosis of the neonatal mouse intestinal microbiome protects against late-onset sepsis.
Journal
Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
05
10
2018
accepted:
03
10
2019
pubmed:
9
11
2019
medline:
21
1
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
Late-onset sepsis (LOS) is thought to result from systemic spread of commensal microbes from the intestines of premature infants. Clinical use of probiotics for LOS prophylaxis has varied owing to limited efficacy, reflecting an incomplete understanding of relationships between development of the intestinal microbiome, neonatal dysbiosis and LOS. Using a model of LOS, we found that components of the developing microbiome were both necessary and sufficient to prevent LOS. Maternal antibiotic exposure that eradicated or enriched transmission of Lactobacillus murinus exacerbated and prevented disease, respectively. Prophylactic administration of some, but not all Lactobacillus spp. was protective, as was administration of Escherichia coli. Intestinal oxygen level was a major driver of colonization dynamics, albeit via mechanisms distinct from those in adults. These results establish a link between neonatal dysbiosis and LOS, and provide a basis for rational selection of probiotics that modulate primary succession of the microbiome to prevent disease.
Identifiants
pubmed: 31700190
doi: 10.1038/s41591-019-0640-y
pii: 10.1038/s41591-019-0640-y
pmc: PMC7250008
mid: NIHMS1563256
doi:
Substances chimiques
Protective Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1772-1782Subventions
Organisme : NCATS NIH HHS
ID : UL1 TR003096
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007051
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013148
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK105680
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR050948
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001417
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008361
Pays : United States
Commentaires et corrections
Type : CommentIn
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