Macrophage migration inhibitory factor promoter polymorphisms are associated with disease activity in rheumatoid arthritis patients from Southern Mexico.
DAS28
MIF
genetic susceptibility
polymorphisms
rheumatoid arthritis
Journal
Molecular genetics & genomic medicine
ISSN: 2324-9269
Titre abrégé: Mol Genet Genomic Med
Pays: United States
ID NLM: 101603758
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
08
04
2019
revised:
23
09
2019
accepted:
11
10
2019
pubmed:
9
11
2019
medline:
27
3
2021
entrez:
9
11
2019
Statut:
ppublish
Résumé
Macrophage migration inhibitory factor (MIF) is a cytokine capable of stimulating inflammatory cytokine and matrix metalloproteinase production from macrophages and synovial fibroblasts, which leads to persistent inflammation and bone degradation, two of the major pathological processes in rheumatoid arthritis (RA). The aim of this study was to evaluate the association of MIF promoter polymorphisms (-794CATT A case-control study was conducted in 200 RA patients and 200 control subjects (CS) from Southern Mexico. Genotyping was performed by conventional PCR and PCR-RFLP methods. MIF mRNA expression was quantified by real-time PCR and MIF serum levels were determined by an ELISA kit. The 7,7 (-794CATT These results suggest an important role of MIF polymorphisms and MIF serum levels with disease activity in RA.
Sections du résumé
BACKGROUND
Macrophage migration inhibitory factor (MIF) is a cytokine capable of stimulating inflammatory cytokine and matrix metalloproteinase production from macrophages and synovial fibroblasts, which leads to persistent inflammation and bone degradation, two of the major pathological processes in rheumatoid arthritis (RA). The aim of this study was to evaluate the association of MIF promoter polymorphisms (-794CATT
METHODS
A case-control study was conducted in 200 RA patients and 200 control subjects (CS) from Southern Mexico. Genotyping was performed by conventional PCR and PCR-RFLP methods. MIF mRNA expression was quantified by real-time PCR and MIF serum levels were determined by an ELISA kit.
RESULTS
The 7,7 (-794CATT
CONCLUSION
These results suggest an important role of MIF polymorphisms and MIF serum levels with disease activity in RA.
Identifiants
pubmed: 31701681
doi: 10.1002/mgg3.1037
pmc: PMC6978234
doi:
Substances chimiques
Macrophage Migration-Inhibitory Factors
0
RNA, Messenger
0
Intramolecular Oxidoreductases
EC 5.3.-
MIF protein, human
EC 5.3.2.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1037Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR049610
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Informations de copyright
© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.
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