The effect of pretreatment submucosal injections of tramadol and dexamethasone on post-endodontic pain in mandibular molar teeth with symptomatic irreversible pulpitis: a randomized controlled clinical trial.


Journal

International endodontic journal
ISSN: 1365-2591
Titre abrégé: Int Endod J
Pays: England
ID NLM: 8004996

Informations de publication

Date de publication:
Feb 2020
Historique:
received: 16 06 2019
accepted: 06 11 2019
pubmed: 9 11 2019
medline: 11 1 2020
entrez: 9 11 2019
Statut: ppublish

Résumé

To establish the effects of submucosal single doses of two medicines on postoperative pain after root canal treatment in mandibular molar teeth with symptomatic irreversible pulpitis. In this randomized controlled, double-blind clinical trial, 90 patients with the diagnosis of symptomatic irreversible pulpitis in their mandibular first or second molars were included and randomly divided into three groups (n = 30): a control group that received normal saline and two experimental groups that received a single dose of either tramadol (100 mg 2 mL At the 6-h and 48-h time intervals, the intensity of pain was significantly less in both the dexamethasone and tramadol groups than in the control group (P < 0.0167). At the end of 12 h, the pain level in the dexamethasone group was significantly less compared to the other groups (P < 0.0167). Pretreatment submucosal dexamethasone and tramadol injections significantly diminished post-treatment endodontic pain of patients with symptomatic irreversible pulpitis following single-visit root canal treatment. However, dexamethasone was more effective than tramadol in pain reduction in the first 12 h.

Identifiants

pubmed: 31702056
doi: 10.1111/iej.13246
doi:

Substances chimiques

Anesthetics, Local 0
Tramadol 39J1LGJ30J
Dexamethasone 7S5I7G3JQL

Types de publication

Journal Article Randomized Controlled Trial

Langues

eng

Pagination

176-185

Informations de copyright

© 2019 International Endodontic Journal. Published by John Wiley & Sons Ltd.

Références

Albashaireh ZS, Alnegrish AS (1998) Postobturation pain after single- and multiple-visit endodontic therapy. A prospective study. Journal of Dentistry 26, 227-32.
Arias A, de la Macorra JC, Hidalgo JJ, Azabal M (2013) Predictive models of pain following root canal treatment: a prospective clinical study. International Endodontic Journal 46, 784-93.
Arora M, Sangwan P, Tewari S, Duhan J (2016) Effect of maintaining apical patency on endodontic pain in posterior teeth with pulp necrosis and apical periodontitis: a randomized controlled trial. International Endodontic Journal J 49, 317-24.
De Pedro-Muñoz A, Mena-Álvarez J (2017) The effect of preoperative submucosal administration of tramadol on the success rate of inferior alveolar nerve block on mandibular molars with symptomatic irreversible pulpitis: a randomized, double-blind placebo-controlled clinical trial. International Endodontic Journal 50, 1134-42.
DiRenzo A, Gresla T, Johnson BR, Rogers M, Tucker D, BeGole EA (2002) Postoperative pain after 1- and 2-visit root canal therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Oral Endodontics 93, 605-10.
Doroschak AM, Bowles WR, Hargreaves KM (1999) Evaluation of the combination of flurbiprofen and tramadol for management of endodontic pain. Journal of Endodontics 25, 660-3.
Elkhadem A, Ezzat K, Ramadan M et al. (2018) The effect of preoperative oral administration of prednisolone on postoperative pain in patients with symptomatic irreversible pulpitis: a single-centre randomized controlled trial. International Endodontic Journal 51, 189-96.
Flath RK, Hicks ML, Dionne RA, Pelleu GB Jr (1987) Pain suppression after pulpectomy with preoperative flurbiprofen. Journal of Endodontics 13, 339-47.
Fuller M, Younkin K, Drum M, Reader A, Nusstein J, Fowler S (2018) Postoperative pain management with oral methylprednisolone in symptomatic patients with a pulpal diagnosis of necrosis: a prospective randomized, double-blind study. Journal of Endodontics 44, 1457-61.
Glennon JP, Ng YL, Setchell DJ, Gulabivala K (2004) Prevalence of and factors affecting postpreparation pain in patients undergoing two-visit root canal treatment. International Endodontic Journal 37, 29-37.
Gopikrishna V, Parameswaran A (2003) Effectiveness of prophylactic use of rofecoxib in comparison with ibuprofen on postendodontic pain. Journal of Endodontics 29, 62-4.
Grond S, Sablotzki A (2004) Clinical pharmacology of tramadol. Clinical Pharmacokinetics 43, 879-923.
Ince B, Ercan E, Dalli M, Dulgergil TC, Zorba YO, Colak H (2009) Incidence of postoperative pain after single- and multi-visit endodontic treatment in teeth with vital and non-vital pulp. European Journal of Dentistry 3, 273-9.
Isiordia-Espinoza MA, Orozco-Solis M, Tobías-Azúa FJ, Méndez-Gutiérrez EP (2012) Submucous tramadol increases the anesthetic efficacy of mepivacaine with epinephrine in inferior alveolar nerve block. British Journal of Oral and Maxillofacial Surgery 50, 157-60.
Jalalzadeh SM, Mamavi A, Shahriari S, Santos FA, Pochapski MT (2010) Effect of pretreatment prednisolone on postendodontic pain: a double-blind parallel-randomized clinical trial. Journal of Endodontics 36, 978-81.
Kan E, Coelho MS, Reside J, Card SJ, Tawil PZ (2016) Periapical microsurgery: the effects of locally injected dexamethasone on pain, swelling, bruising, and wound healing. Journal of Endodontics 42, 1608-12.
Keiser K, Hargreaves KM (2002) Building effective strategies for the management of endodontic pain. Endodontic Topics 1, 93-105.
Krasner P, Jackson E (1986) The use of oral dexamethasone in the treatment of posttreatment endodontic pain. Oral Surgery, Oral Medicine, Oral Pathology 62, 187-90.
Law AS, Nixdorf DR, Aguirre AM et al. (2015) Predicting severe pain after root canal therapy in the National Dental PBRN. Journal of Dental Research 94, 37S-43S.
Liesinger A, Marshall FJ, Marshall JG (1993) Effect of variable doses of dexamethasone on posttreatment endodontic pain. Journal of Endodontics 19, 35-9.
Marshall JG (2002) Consideration of steroids for endodontic pain. Endodontic Topics 3, 41-51.
Marshall JG, Liesinger AW (1993) Factors associated with endodontic posttreatment pain. Journal of Endodontics 19, 573-5.
Marshall JG, Walton RE (1984) The effect of intramuscular injection of steroid on posttreatment endodontic pain. Journal of Endodontics 10, 585-8.
Mehrvarzfar P, Abbott PV, Saghiri MA et al. (2012) Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial. International Endodontic Journal 45, 76-82.
Mehrvarzfar P, Esnashari E, Salmanzadeh R, Fazlyab M, Fazlyab M (2016) Effect of dexamethasone intraligamentary Injection on post-endodontic pain in patients with symptomatic irreversible pulpitis: a randomized controlled clinical trial. Iranian Endodontic Journal 11, 261-6.
Mohammadi Z (2009) Systemic and local applications of steroids in endodontics: an updated review. International Dental Journal 59, 297-304.
Morse DR, Koren LZ, Esposito JV et al. (1986) Asymptomatic teeth with necrotic pulps and associated periapical radiolucencies: relationship of flare-ups to endodontic instrumentation, antibiotic usage and stress in three separate practices at three different time periods. International Journal of Psychosomatics 33, 5-87.
Ng YL, Glennon JP, Setchell DJ, Gulabivala K (2004) Prevalence of and factors affecting post-obturation pain in patients undergoing root canal treatment. International Endodontic Journal 37, 381-91.
Pak JG, White SN (2011) Pain prevalence and severity before, during, and after root canal treatment: a systematic review. Journal of Endodontics 37, 429-38.
Pochapski MT, Santos FA, de Andrade ED, Sydney GB (2009) Effect of pretreatment dexamethasone on postendodontic pain. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Oral Endodontics 108, 790-5.
Pozos AJ, Martınez R, Aguirre P, Perez J (2006) The effects of tramadol added to articaine on anesthesia duration. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Oral Endodontics 102, 614-7.
Praveen R, Thakur S, Kirthiga M (2017) Comparative evaluation of premedication with ketorolac and prednisolone on postendodontic pain: a double-blind randomized controlled trial. Journal of Endodontics 43, 667-73.
Rodríguez-Wong L, Pozos-Guillen A, Silva-Herzog D, Chavarría-Bolaños D (2016) Efficacy of mepivacaine-tramadol combination on the success of inferior alveolar nerve blocks in patients with symptomatic irreversible pulpitis: a randomized clinical trial. International Endodontic Journal 49, 325-33.
Rogers MJ, Johnson BR, Remeikis NA, BeGole EA (1999) Comparison of effect of intracanal use of ketorolac tromethamine and dexamethasone with oral ibuprofen on post treatment endodontic pain. Journal of Endodontics 25, 381-4.
Sathorn C, Parashos P, Messer H (2008) The prevalence of postoperative pain and flare-up in single- and multiple-visit endodontic treatment: a systematic review. International Endodontic Journal 41, 91-9.
Shahi S, Asghari V, Rahimi S et al. (2016) Postoperative pain after endodontic treatment of asymptomatic teeth using rotary instruments: a randomized clinical trial. Iranian Endodontic Journal 11, 38-43.
Shantiaee Y, Mahjour F, Dianat O (2012) Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain. International Dental Journal 62, 74-8.
Sharma N, Nikhil V, Gupta S (2015) Effect of preoperative administration of steroid with different routes on post endodontic pain: a randomized placebo controlled clinical trial. Endodontology 27, 107-12.
Stenholm E, Bongenhielm U, Ahlquist M, Fried K (2002) VRl- and VRL-l-like immunoreactivity in normal and injured trigeminal dental primary sensory neurons of the rat. Acta Odontologica Scandinavica 60, 72-9.
Suneelkumar C, Subha A, Gogala D (2018) Effect of preoperative corticosteroids in patients with symptomatic pulpitis on postoperative pain after single-visit root canal treatment: a systematic review and meta-analysis. Journal of Endodontics 44, 1347-54.
Torabinejad M, Cymerman JJ, Frankson M, Lemon RR, Maggio JD, Schilder H (1994) Effectiveness of various medications on postoperative pain following complete instrumentation. Journal of Endodontics 20, 345-54.
Wong AW, Zhang C, Chu CH (2014) A systematic review of nonsurgical single-visit versus multiple-visit endodontic treatment. Clinical, Cosmetic and Investigational Dentistry 6, 45-56.

Auteurs

F Aksoy (F)

Department of Endodontics, Faculty of Dentistry, Adiyaman University, Adiyaman, Turkey.

B Ege (B)

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Adiyaman University, Adiyaman, Turkey.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH