A cellular antidote to specifically deplete anti-CD19 chimeric antigen receptor-positive cells.
Journal
Blood
ISSN: 1528-0020
Titre abrégé: Blood
Pays: United States
ID NLM: 7603509
Informations de publication
Date de publication:
13 02 2020
13 02 2020
Historique:
received:
02
06
2019
accepted:
05
11
2019
pubmed:
9
11
2019
medline:
22
7
2020
entrez:
9
11
2019
Statut:
ppublish
Résumé
Unintentional transduction of B-cell acute lymphoblastic leukemia blasts during CART19 manufacturing can lead to CAR19+ leukemic cells (CARB19) that are resistant to CART19 killing. We developed an anti-CAR19 idiotype chimeric antigen receptor (αCAR19) to specifically recognize CAR19+ cells. αCAR19 CAR T cells efficiently lysed CARB19 cells in vitro and in a primary leukemia-derived xenograft model. We further showed that αCAR19-CART cells could be used as an "antidote" to deplete CART19 cells to reduce long-term side effects, such as B-cell aplasia.
Identifiants
pubmed: 31703119
pii: S0006-4971(20)62252-2
doi: 10.1182/blood.2019001859
pmc: PMC7019191
doi:
Substances chimiques
Antigens, CD19
0
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
505-509Subventions
Organisme : NCI NIH HHS
ID : K99 CA212302
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA214278
Pays : United States
Organisme : NCI NIH HHS
ID : R00 CA212302
Pays : United States
Commentaires et corrections
Type : CommentIn
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