Baicalein as a Potential Inhibitor against BACE1 and AChE: Mechanistic Comprehension through In Vitro and Computational Approaches.
ATP Binding Cassette Transporter, Subfamily B, Member 1
/ chemistry
Acetylcholinesterase
/ chemistry
Alzheimer Disease
Amyloid Precursor Protein Secretases
/ antagonists & inhibitors
Aspartic Acid Endopeptidases
/ antagonists & inhibitors
Cholinesterase Inhibitors
/ chemistry
Flavanones
/ chemistry
Humans
Molecular Docking Simulation
Recombinant Proteins
/ chemistry
Scutellaria baicalensis
Alzheimer’s disease
Aβ
BACE1
Lipinski’s rules
baicalein
docking analysis
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
07 Nov 2019
07 Nov 2019
Historique:
received:
14
10
2019
revised:
28
10
2019
accepted:
04
11
2019
entrez:
10
11
2019
pubmed:
11
11
2019
medline:
6
5
2020
Statut:
epublish
Résumé
One of the major neurodegenerative features of Alzheimer's disease (AD) is the presence of neurotoxic amyloid plaques composed of amyloid beta peptide (Aβ). β-Secretase (BACE1) and acetylcholinesterase (AChE), which promote Aβ fibril formation, have become attractive therapeutic targets for AD. P-glycoprotein (P-gp), the major efflux pump of the blood-brain barrier (BBB), plays a critical role in limiting therapeutic molecules. In pursuit of discovering a natural anti-AD candidate, the bioactivity, physicochemical, drug-likeness, and molecular docking properties of baicalein, a major compound from
Identifiants
pubmed: 31703329
pii: nu11112694
doi: 10.3390/nu11112694
pmc: PMC6893645
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
Cholinesterase Inhibitors
0
Flavanones
0
Recombinant Proteins
0
baicalein
49QAH60606
Acetylcholinesterase
EC 3.1.1.7
Amyloid Precursor Protein Secretases
EC 3.4.-
Aspartic Acid Endopeptidases
EC 3.4.23.-
BACE1 protein, human
EC 3.4.23.46
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Dong-A University
ID : Not applicable
Références
Neuropsychiatr Dis Treat. 2016 Dec 09;12:3145-3152
pubmed: 28003750
Food Chem Toxicol. 2014 Feb;64:27-33
pubmed: 24291393
CNS Drugs. 2017 Aug;31(8):639-652
pubmed: 28634902
J Pharm Biomed Anal. 2014 Aug;97:9-23
pubmed: 24803030
Biochim Biophys Acta. 2012 Jun;1822(6):885-96
pubmed: 22306812
Nutrients. 2019 Mar 19;11(3):
pubmed: 30893825
Br J Pharmacol. 2002 Dec;137(8):1314-20
pubmed: 12466241
Mol Cell Biol. 2008 Jun;28(11):3663-71
pubmed: 18378702
J Biol Chem. 2001 Jun 29;276(26):23282-7
pubmed: 11313335
J Mol Neurosci. 2010 Mar;40(3):311-20
pubmed: 19731100
EMBO Mol Med. 2016 Jun 01;8(6):595-608
pubmed: 27025652
Biopharm Drug Dispos. 2011 Nov;32(8):427-45
pubmed: 21928297
PLoS One. 2015 Aug 28;10(8):e0136397
pubmed: 26317778
Biomed Pharmacother. 2017 Nov;95:1021-1032
pubmed: 28922719
CNS Neurol Disord Drug Targets. 2014;13(8):1432-9
pubmed: 25345511
Clin Drug Investig. 2016 Sep;36(9):713-724
pubmed: 27352310
Molecules. 2018 Jun 22;23(7):
pubmed: 29932100
J Agric Food Chem. 2004 Jun 30;52(13):4128-32
pubmed: 15212458
Fitoterapia. 2012 Apr;83(3):532-40
pubmed: 22245084
J Neurochem. 2014 Jul;130(1):4-28
pubmed: 24646365
Neuroreport. 2001 Jul 20;12(10):2199-202
pubmed: 11447334
Biol Pharm Bull. 2003 Jan;26(1):79-83
pubmed: 12520178
J Pharm Pharmacol. 2000 Dec;52(12):1563-8
pubmed: 11197087
Bioorg Med Chem Lett. 2011 May 15;21(10):2945-8
pubmed: 21511472
Essays Biochem. 2011 Sep 7;50(1):161-78
pubmed: 21967057
J Neurosci Res. 2013 Sep;91(9):1239-46
pubmed: 23686791
Adv Drug Deliv Rev. 1995 Jul;15(1-3):5-36
pubmed: 35524389
FEBS J. 2008 Feb;275(4):625-32
pubmed: 18205831
FASEB J. 2011 Feb;25(2):775-84
pubmed: 21059748
Nat Rev Neurosci. 2002 Apr;3(4):281-90
pubmed: 11967558
Behav Brain Res. 2016 Sep 15;311:309-321
pubmed: 27233830
Pharm Res. 2011 May;28(5):943-8
pubmed: 20967491
J Neurochem. 2007 Feb;100(3):802-9
pubmed: 17156133
Br J Pharmacol. 2008 Dec;155(8):1279-96
pubmed: 18776918
Hum Mol Genet. 2001 Jun 1;10(12):1317-24
pubmed: 11406613
Inorg Chem. 2018 Jul 2;57(13):7524-7535
pubmed: 29893118