Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica.
Ajaniaolide B
Anti-inflammation
Artemdubolide I
Artemisia heptapotamica
Artemisiane E
Sesquiterpene lactone
Journal
Chinese journal of natural medicines
ISSN: 1875-5364
Titre abrégé: Chin J Nat Med
Pays: China
ID NLM: 101504416
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
27
06
2019
entrez:
10
11
2019
pubmed:
11
11
2019
medline:
19
3
2020
Statut:
ppublish
Résumé
One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-κB induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC
Identifiants
pubmed: 31703759
pii: S1875-5364(19)30095-0
doi: 10.1016/S1875-5364(19)30095-0
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Lactones
0
NF-kappa B
0
Plant Extracts
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
785-791Informations de copyright
Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.