Increased Immunosuppression Is Related to Increased Amounts of Ascites and Inferior Prognosis in Ovarian Cancer.
Adenocarcinoma, Clear Cell
/ drug therapy
Adenocarcinoma, Mucinous
/ drug therapy
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Ascites
/ etiology
Cystadenocarcinoma, Serous
/ drug therapy
Endometrial Neoplasms
/ drug therapy
Female
Follow-Up Studies
Humans
Immunosuppression Therapy
/ mortality
Middle Aged
Neoadjuvant Therapy
/ adverse effects
Neoplasm Invasiveness
Ovarian Neoplasms
/ drug therapy
Prognosis
Prospective Studies
Retrospective Studies
Survival Rate
Young Adult
Ovarian cancer
ascites
immunosuppression
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
27
09
2019
revised:
11
10
2019
accepted:
14
10
2019
entrez:
10
11
2019
pubmed:
11
11
2019
medline:
26
11
2019
Statut:
ppublish
Résumé
The presence of ascites in ovarian cancer patients is considered a negative prognostic factor. The underlying mechanisms are not clearly understood. The amount of ascites was evaluated, preferably, using diffusion-weighted MRI at primary diagnosis in a retrospective cohort of 214 women with ovarian cancer, in an ordinal manner (amount of ascites: none, limited, moderate, abundant). In a prospective cohort comprising 45 women with ovarian cancer, IL-10 (interleukin), VEGF (vascular endothelial growth factor), TGF-β (transforming growth factor) and CCL-2 [chemokine (C-C) motif ligand 2] were measured at diagnosis (and at interval debulking, when available). Gradually increasing amounts of ascites were correlated significantly, even after correction for FIGO stage, with reduced survival (p<0.0001) and stronger immunosuppression (IL10 and VEGF). Neoadjuvant chemotherapy reduced immunosuppression, which was observed as a reduction in CCL-2, IL-10 and VEGF. The amount of ascites is an independent predictor of survival and correlates with increased immunosuppression.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The presence of ascites in ovarian cancer patients is considered a negative prognostic factor. The underlying mechanisms are not clearly understood.
MATERIALS AND METHODS
METHODS
The amount of ascites was evaluated, preferably, using diffusion-weighted MRI at primary diagnosis in a retrospective cohort of 214 women with ovarian cancer, in an ordinal manner (amount of ascites: none, limited, moderate, abundant). In a prospective cohort comprising 45 women with ovarian cancer, IL-10 (interleukin), VEGF (vascular endothelial growth factor), TGF-β (transforming growth factor) and CCL-2 [chemokine (C-C) motif ligand 2] were measured at diagnosis (and at interval debulking, when available).
RESULTS
RESULTS
Gradually increasing amounts of ascites were correlated significantly, even after correction for FIGO stage, with reduced survival (p<0.0001) and stronger immunosuppression (IL10 and VEGF). Neoadjuvant chemotherapy reduced immunosuppression, which was observed as a reduction in CCL-2, IL-10 and VEGF.
CONCLUSION
CONCLUSIONS
The amount of ascites is an independent predictor of survival and correlates with increased immunosuppression.
Identifiants
pubmed: 31704820
pii: 39/11/5953
doi: 10.21873/anticanres.13800
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5953-5962Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.