Intra-abdominal recurrence from colorectal carcinoma: Differences and similarities between local and peritoneal recurrence.
Adenocarcinoma, Mucinous
/ pathology
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Carcinoma, Signet Ring Cell
/ pathology
Colorectal Neoplasms
/ pathology
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Hyperthermia, Induced
/ mortality
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Recurrence, Local
/ pathology
Peritoneal Neoplasms
/ secondary
Prognosis
Prospective Studies
Survival Rate
Cytoreductive surgery
HIPEC
Local recurrence
Lymph node metastasis
Peritoneal recurrence
Journal
Surgical oncology
ISSN: 1879-3320
Titre abrégé: Surg Oncol
Pays: Netherlands
ID NLM: 9208188
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
28
11
2018
revised:
12
02
2019
accepted:
28
10
2019
pubmed:
11
11
2019
medline:
31
10
2020
entrez:
11
11
2019
Statut:
ppublish
Résumé
Peritoneal recurrences from colo-rectal cancer can be isolated (PR) or associated with local recurrences (LR). The purpose of this study was to analyze patterns and outcomes of LR and PR. Analyze from a prospective database of 108 patients treated with CCS plus HIPEC at two cancer centers between 2008 and 2015. The population was divided into an LPR group (presence of LR with or without PR, n = 56) and a PR group (isolated PR, n = 52). The patients characteristics (age, sex, Charlson score, PCI) or perioperative treatments were comparable between the groups. The median number of resected organs for tumor involvement (respectively, 2 vs 1; p < 0.001), the percentage of patients with metastatic lymph nodes (LN+) from the resected specimen (respectively, 25% vs 7%; p = 0.016) and the mortality rate (respectively, 9% vs 0%; p = 0.023) were significantly higher in the LPR group. After a median follow-up of 32 (1-108) months, median overall survival was comparable between the two groups (respectively, 46 vs 42 months; p = 0.262). LR is associated with a higher incidence of organ invasion, LN involvement (25%) and postoperative mortality. Optimal surgical resection of LR with systematic lymphadenectomy of invaded organs seems mandatory.
Sections du résumé
BACKGROUND
BACKGROUND
Peritoneal recurrences from colo-rectal cancer can be isolated (PR) or associated with local recurrences (LR). The purpose of this study was to analyze patterns and outcomes of LR and PR.
METHODS
METHODS
Analyze from a prospective database of 108 patients treated with CCS plus HIPEC at two cancer centers between 2008 and 2015.
RESULTS
RESULTS
The population was divided into an LPR group (presence of LR with or without PR, n = 56) and a PR group (isolated PR, n = 52). The patients characteristics (age, sex, Charlson score, PCI) or perioperative treatments were comparable between the groups. The median number of resected organs for tumor involvement (respectively, 2 vs 1; p < 0.001), the percentage of patients with metastatic lymph nodes (LN+) from the resected specimen (respectively, 25% vs 7%; p = 0.016) and the mortality rate (respectively, 9% vs 0%; p = 0.023) were significantly higher in the LPR group. After a median follow-up of 32 (1-108) months, median overall survival was comparable between the two groups (respectively, 46 vs 42 months; p = 0.262).
CONCLUSIONS
CONCLUSIONS
LR is associated with a higher incidence of organ invasion, LN involvement (25%) and postoperative mortality. Optimal surgical resection of LR with systematic lymphadenectomy of invaded organs seems mandatory.
Identifiants
pubmed: 31707314
pii: S0960-7404(18)30472-9
doi: 10.1016/j.suronc.2019.10.018
pii:
doi:
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
23-29Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.