Risk of New-Onset Atrial Fibrillation Among Asian Chronic Hepatitis C Virus Carriers: A Nationwide Population-Based Cohort Study.
Adult
Aged
Antiviral Agents
/ therapeutic use
Atrial Fibrillation
/ epidemiology
Cohort Studies
Comorbidity
Diabetes Mellitus
/ epidemiology
Dyslipidemias
/ epidemiology
Female
Heart Disease Risk Factors
Hepatitis C, Chronic
/ drug therapy
Humans
Hypertension
/ epidemiology
Incidence
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Taiwan
/ epidemiology
atrial fibrillation
chronic hepatitis C
extrahepatic manifestations
inflammation
population‐based cohort study
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
19 11 2019
19 11 2019
Historique:
entrez:
13
11
2019
pubmed:
13
11
2019
medline:
15
12
2020
Statut:
ppublish
Résumé
Background Hepatitis C virus (HCV) infection not only links closely to systemic inflammation but also has numerous extrahepatic manifestations. Chronic inflammation also increases the risk of new-onset atrial fibrillation (AF). However, little is known regarding the clinical association between HCV infection and new-onset AF. Methods and Results We conducted a population-based cohort study using Taiwan's National Health Insurance Research Database during 1997 to 2013. A total of 11 771 HCV-infected patients were included in this study, and each of them was matched in a ratio of 1:4. Because of higher mortality among HCV cohorts, we used both Cox proportional hazard regression and competing risk regression models to compute the hazard ratios accompanying 95% CIs after adjustment for relevant confounder. The results demonstrated that the patients with chronic HCV infection had significantly higher incidence rate (332.0 versus 265.8 in 100 000 person-years,
Identifiants
pubmed: 31711382
doi: 10.1161/JAHA.119.012914
pmc: PMC6915266
doi:
Substances chimiques
Antiviral Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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