Alcohol intake during pregnancy and timing of puberty in sons and daughters: A nationwide cohort study.
Alcohol
Maternal exposure
Menarche
Prenatal exposure delayed effects
Puberty
Journal
Reproductive toxicology (Elmsford, N.Y.)
ISSN: 1873-1708
Titre abrégé: Reprod Toxicol
Pays: United States
ID NLM: 8803591
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
28
06
2019
revised:
06
11
2019
accepted:
07
11
2019
pubmed:
13
11
2019
medline:
29
12
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
We explored whether maternal alcohol intake in early pregnancy is associated with pubertal timing in sons and daughters. In total, 15,819 children, born 2000-2003 within the Danish National Birth Cohort, gave half-yearly, self-reported information on pubertal development (Tanner stages, voice break, first ejaculation, menarche, acne, and axillary hair) from 11 years during 2012-2018. Information on maternal average alcohol intake in first trimester and binge drinking episodes (intake of ≥5 drinks on the same occasion) in first trimester was self-reported by mothers during pregnancy. Average alcohol intake of 5+ weekly drinks in first trimester was not associated with pubertal timing in sons (with no alcohol intake as the reference). A tendency towards earlier pubertal timing was observed in daughters (-2.0 (95 % confidence interval: -4.2, 0.3) months) when combining the estimates for all pubertal milestones. Binge drinking was not associated with pubertal timing in neither sons nor daughters.
Identifiants
pubmed: 31711902
pii: S0890-6238(19)30316-8
doi: 10.1016/j.reprotox.2019.11.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-42Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.