Basic residues within the cardiac troponin T C terminus are required for full inhibition of muscle contraction and limit activation by calcium.
Actin Cytoskeleton
/ chemistry
Actins
/ chemistry
Adenosine Triphosphatases
/ chemistry
Alanine
/ chemistry
Animals
Arginine
/ chemistry
Calcium
/ chemistry
Fluorescence Resonance Energy Transfer
Fluorescent Dyes
/ chemistry
Humans
Kinetics
Lysine
/ chemistry
Muscle Contraction
Mutation
Myosins
/ chemistry
Protein Binding
Protein Conformation
Protein Domains
Rabbits
Stress, Mechanical
Swine
Tropomyosin
/ chemistry
Troponin T
/ chemistry
ATPase activity
cardiac muscle
cross-bridge kinetics
fluorescence resonance energy transfer (FRET)
high Ala, high activation TnT (HAHA TnT)
muscle physiology
states of actin
tropomyosin
troponin
troponin T (TnT)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
20 12 2019
20 12 2019
Historique:
received:
05
09
2019
revised:
08
11
2019
pubmed:
13
11
2019
medline:
23
6
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
Striated muscle is activated by myosin- and actin-linked processes, with the latter being regulated through changes in the position of tropomyosin relative to the actin surface. The C-terminal region of cardiac troponin T (TnT), a tropomyosin-associated protein, is required for full TnT inactivation at low Ca
Identifiants
pubmed: 31712308
pii: S0021-9258(20)30270-2
doi: 10.1074/jbc.RA119.010966
pmc: PMC6926443
doi:
Substances chimiques
Actins
0
Fluorescent Dyes
0
TNNT2 protein, human
0
Tropomyosin
0
Troponin T
0
Arginine
94ZLA3W45F
Adenosine Triphosphatases
EC 3.6.1.-
Myosins
EC 3.6.4.1
Lysine
K3Z4F929H6
Alanine
OF5P57N2ZX
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19535-19545Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR035216
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL128683
Pays : United States
Informations de copyright
© 2019 Johnson et al.
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