Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
29
05
2019
accepted:
30
10
2019
revised:
29
10
2019
pubmed:
13
11
2019
medline:
28
1
2022
entrez:
13
11
2019
Statut:
ppublish
Résumé
Panic disorder (PD) has a lifetime prevalence of 2-4% and heritability estimates of 40%. The contributory genetic variants remain largely unknown, with few and inconsistent loci having been reported. The present report describes the largest genome-wide association study (GWAS) of PD to date comprising genome-wide genotype data of 2248 clinically well-characterized PD patients and 7992 ethnically matched controls. The samples originated from four European countries (Denmark, Estonia, Germany, and Sweden). Standard GWAS quality control procedures were conducted on each individual dataset, and imputation was performed using the 1000 Genomes Project reference panel. A meta-analysis was then performed using the Ricopili pipeline. No genome-wide significant locus was identified. Leave-one-out analyses generated highly significant polygenic risk scores (PRS) (explained variance of up to 2.6%). Linkage disequilibrium (LD) score regression analysis of the GWAS data showed that the estimated heritability for PD was 28.0-34.2%. After correction for multiple testing, a significant genetic correlation was found between PD and major depressive disorder, depressive symptoms, and neuroticism. A total of 255 single-nucleotide polymorphisms (SNPs) with p < 1 × 10
Identifiants
pubmed: 31712720
doi: 10.1038/s41380-019-0590-2
pii: 10.1038/s41380-019-0590-2
doi:
Banques de données
ClinicalTrials.gov
['NCT01323556']
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4179-4190Subventions
Organisme : NIMH NIH HHS
ID : U24 MH068457
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD042157
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089951
Pays : United States
Organisme : NIMH NIH HHS
ID : RC2 MH089995
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109514
Pays : United States
Informations de copyright
© 2019. The Author(s), under exclusive licence to Springer Nature Limited.
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