Acetaminophen poisoning-induced heart injury: a case-based review.
Acetaminophen
Acute poisoning
Cardiotoxicity
Heart injury
Overdose
Paracetamol
Journal
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
ISSN: 2008-2231
Titre abrégé: Daru
Pays: Switzerland
ID NLM: 101125969
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
17
04
2019
accepted:
11
10
2019
pubmed:
13
11
2019
medline:
10
4
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
Acetaminophen (Paracetamol, APAP) poisoning is frequently implicated in self-harm. Cases of acetaminophen-associated cardiotoxicity are rare in relation to the number of patients with acetaminophen poisoning. A review of acetaminophen cardiotoxicity in 1996 concluded that there was no decisive evidence demonstrating that acetaminophen overdose has a cardiotoxic effect. This review study aimed to determine whether acetaminophen could induce heart injury. We searched for keywords of acetaminophen, paracetamol, cardiotoxicity, heart injury, heart damage, myocarditis, pericarditis, myocardial infarction, and myocardial ischemia in Web of Science, PubMed, Scopus, Embase, Google Scholar, and Persian databases. The search included articles published from January 1950 to October 2018 with no language restrictions. The search yielded 64 citations in English; 36 of the articles were excluded as they were not relevant; 5 articles were excluded since they were duplicates, leaving 23 articles. Full-text articles of the 23 citations were obtained and reviewed. Myocardial infarction, heart dysfunction and failure, cardiac arrhythmias, pericarditis, heart cell necrosis, and sudden cardiac death were reported in acetaminophen overdose. Ddysrhythmias, heart failure, and various other cardiac effects could occur following acetaminophen induced hepatic failure. However, the evidence for direct injury on cardiac tissue is weak. Graphical abstract Potential mechanisms for cardiotoxicity of acetaminophen.
Identifiants
pubmed: 31713183
doi: 10.1007/s40199-019-00307-x
pii: 10.1007/s40199-019-00307-x
pmc: PMC6895290
doi:
Substances chimiques
Acetaminophen
362O9ITL9D
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
839-851Références
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