Antibody response against HERV-W in patients with MOG-IgG associated disorders, multiple sclerosis and NMOSD.
Adult
Aged
Aged, 80 and over
Aquaporin 4
/ immunology
Autoantibodies
/ blood
Female
Gene Products, env
/ immunology
Humans
Immunoglobulin G
/ blood
Male
Middle Aged
Multiple Sclerosis
/ immunology
Myelin-Oligodendrocyte Glycoprotein
/ immunology
Neuromyelitis Optica
/ immunology
Pregnancy Proteins
/ immunology
Retrospective Studies
Autoimmunity
Human endogenous retroviruses
MS
Myelin oligodendrocyte glycoprotein
Neuromyelitis optica spectrum disorder
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
17
07
2019
revised:
18
10
2019
accepted:
04
11
2019
pubmed:
13
11
2019
medline:
14
7
2020
entrez:
13
11
2019
Statut:
ppublish
Résumé
Increased expression of the retroviruses of HERV-W family has been linked to multiple sclerosis (MS) pathophysiology; nothing is known at the moment about MOG-IgG associated disorders. We compared antibody response against HERV-W peptides among patients with MOG-IgG associated disorders, multiple sclerosis (MS) and aquaporin-4 (AQP4)-IgG positive neuromyelitis optica spectrum disorder (NMOSD). A total of 102 serum samples were retrospectively analyzed. Antibody reactivity against HERV-W env peptides was similar in MOG-IgG associated disorders and MS, but different from AQP4-IgG positive NMOSD. Our findings expand the diagnostic role of HERV-W antibodies to the spectrum of demyelinating disorders associated with MOG-IgG.
Identifiants
pubmed: 31715457
pii: S0165-5728(19)30359-5
doi: 10.1016/j.jneuroim.2019.577110
pii:
doi:
Substances chimiques
AQP4 protein, human
0
Aquaporin 4
0
Autoantibodies
0
Gene Products, env
0
Immunoglobulin G
0
Myelin-Oligodendrocyte Glycoprotein
0
Pregnancy Proteins
0
syncytin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577110Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.