Short halt in vaping modifies cardiorespiratory parameters and urine metabolome: a randomized trial.
Adult
Biomarkers
/ blood
Blood Pressure
Diffusion
Discriminant Analysis
Heart
/ physiopathology
Heart Rate
Hemodynamics
Hemoglobins
/ metabolism
Humans
Least-Squares Analysis
Lung Injury
/ blood
Metabolome
Microcirculation
Nicotine
/ blood
Oximetry
Oxygen
/ metabolism
Partial Pressure
Regional Blood Flow
Respiration
Respiratory Function Tests
Skin
/ blood supply
Smoking Cessation
Vaping
/ blood
electronic nicotine delivery systems
metabolomics
nicotine
pneumoproteins
transcutaneous oxygen tension
Journal
American journal of physiology. Lung cellular and molecular physiology
ISSN: 1522-1504
Titre abrégé: Am J Physiol Lung Cell Mol Physiol
Pays: United States
ID NLM: 100901229
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
pubmed:
14
11
2019
medline:
13
5
2020
entrez:
14
11
2019
Statut:
ppublish
Résumé
Propylene glycol and glycerol are e-cigarette constituents that facilitate liquid vaporization and nicotine transport. As these small hydrophilic molecules quickly cross the lung epithelium, we hypothesized that short-term cessation of vaping in regular users would completely clear aerosol deposit from the lungs and reverse vaping-induced cardiorespiratory toxicity. We aimed to assess the acute effects of vaping and their reversibility on biological/clinical cardiorespiratory parameters [serum/urine pneumoproteins, hemodynamic parameters, lung-function test and diffusing capacities, transcutaneous gas tensions (primary outcome), and skin microcirculatory blood flow]. Regular e-cigarette users were enrolled in this randomized, investigator-blinded, three-period crossover study. The periods consisted of nicotine-vaping (nicotine-session), nicotine-free vaping (nicotine-free-session), and complete cessation of vaping (stop-session), all maintained for 5 days before the session began. Multiparametric metabolomic analyses were used to verify subjects' protocol compliance. Biological/clinical cardiorespiratory parameters were assessed at the beginning of each session (baseline) and after acute vaping exposure. Compared with the nicotine- and nicotine-free-sessions, a specific metabolomic signature characterized the stop-session. Baseline serum club cell protein-16 was higher during the stop-session than the other sessions (
Identifiants
pubmed: 31721596
doi: 10.1152/ajplung.00268.2019
pmc: PMC7052663
doi:
Substances chimiques
Biomarkers
0
Hemoglobins
0
Nicotine
6M3C89ZY6R
Oxygen
S88TT14065
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
L331-L344Références
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