Activated leukocyte cell adhesion molecule regulates B lymphocyte migration across central nervous system barriers.
Activated-Leukocyte Cell Adhesion Molecule
/ metabolism
Animals
B-Lymphocytes
/ cytology
Blood-Brain Barrier
/ metabolism
Cell Movement
Central Nervous System
/ metabolism
Encephalomyelitis, Autoimmune, Experimental
/ immunology
Endothelium
/ metabolism
Humans
Immunologic Memory
Mice, Knockout
Multiple Sclerosis
/ immunology
Myelin-Oligodendrocyte Glycoprotein
/ immunology
Recombinant Proteins
/ immunology
Severity of Illness Index
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
13 11 2019
13 11 2019
Historique:
received:
26
11
2018
revised:
10
07
2019
accepted:
21
10
2019
entrez:
15
11
2019
pubmed:
15
11
2019
medline:
5
9
2020
Statut:
ppublish
Résumé
The presence of B lymphocyte-associated oligoclonal immunoglobulins in the cerebrospinal fluid is a classic hallmark of multiple sclerosis (MS). The clinical efficacy of anti-CD20 therapies supports a major role for B lymphocytes in MS development. Although activated oligoclonal populations of pathogenic B lymphocytes are able to traffic between the peripheral circulation and the central nervous system (CNS) in patients with MS, molecular players involved in this migration have not yet been elucidated. In this study, we demonstrated that activated leukocyte cell adhesion molecule (ALCAM/CD166) identifies subsets of proinflammatory B lymphocytes and drives their transmigration across different CNS barriers in mouse and human. We also showcased that blocking ALCAM alleviated disease severity in animals affected by a B cell-dependent form of experimental autoimmune encephalomyelitis. Last, we determined that the proportion of ALCAM
Identifiants
pubmed: 31723036
pii: 11/518/eaaw0475
doi: 10.1126/scitranslmed.aaw0475
pii:
doi:
Substances chimiques
Activated-Leukocyte Cell Adhesion Molecule
0
Myelin-Oligodendrocyte Glycoprotein
0
Recombinant Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.