Deletion of the Tensin2 SH2-PTB domain, but not the loss of its PTPase activity, induces podocyte injury in FVB/N mouse strain.

Animals Gene Deletion Mice Mice, Transgenic Podocytes / pathology Protein Tyrosine Phosphatases / metabolism Tensins / genetics
chronic kidney disease focal adhesion nephropathy podocyte tensin

Journal

Experimental animals
ISSN: 1881-7122
Titre abrégé: Exp Anim
Pays: Japan
ID NLM: 9604830

Informations de publication

Date de publication:
24 Apr 2020
Historique:
pubmed: 15 11 2019
medline: 5 8 2020
entrez: 15 11 2019
Statut: ppublish

Résumé

Tensin2 (TNS2) is a focal adhesion-localized protein possessing N-terminal tandem protein tyrosine phosphatase (PTPase) and C2 domains, and C-terminal tandem Src homology 2 (SH2) and phosphotyrosine binding (PTB) domains. Genetic deletion of Tns2 in a susceptible murine strain leads to podocyte alterations after birth. To clarify the domain contributions to podocyte maintenance, we generated two Tns2-mutant mice with the genetic background of the susceptible FVB/NJ strain, Tns2

Identifiants

DOI: 10.1538/expanim.19-0101 PMID: 31723089 PMC: PMC7220710
pubmed: 31723089
doi: 10.1538/expanim.19-0101
pmc: PMC7220710
doi:

Substances chimiques

Tensins 0
Tns2 protein, mouse EC 3.1.3.16
Protein Tyrosine Phosphatases EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

135-143

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Auteurs

Hayato Sasaki (H)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

Yuki Takahashi (Y)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

Tsubasa Ogawa (T)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

Koki Hiura (K)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

Kenta Nakano (K)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.
Department of Laboratory Animal Medicine, Section of Animal Models, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan.

Makoto Sugiyama (M)

Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

Tadashi Okamura (T)

Department of Laboratory Animal Medicine, Section of Animal Models, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku, Tokyo 162-8655, Japan.

Nobuya Sasaki (N)

Laboratory of Laboratory Animal Science and Medicine, School of Veterinary Medicine, Kitasato University, 35-1 Higashi-23, Towada, Aomori 034-8628, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Phénomènes génétiques › Mutagenèse › Délétion de séquence › Délétion de gène › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Deletion of the Tensin2 SH2-PTB domain, but...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Tensines › Deletion of the Tensin2 SH2-PTB domain, but...