Characteristics and short-term outcomes of neonates with mild hypoxic-ischemic encephalopathy treated with hypothermia.
Brain
/ diagnostic imaging
Brain Injuries
/ diagnostic imaging
Canada
Female
Humans
Hypothermia, Induced
/ trends
Hypoxia-Ischemia, Brain
/ complications
Infant, Newborn
Length of Stay
Magnetic Resonance Imaging
Male
Neuroimaging
Patient Acuity
Respiration, Artificial
Retrospective Studies
Selection Bias
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
08
2019
accepted:
28
10
2019
revised:
07
10
2019
pubmed:
15
11
2019
medline:
26
8
2020
entrez:
15
11
2019
Statut:
ppublish
Résumé
To compare the characteristics and outcomes of neonates with mild hypoxic-ischemic encephalopathy (HIE) who received hypothermia versus standard care. We conducted a retrospective cohort study of neonates ≥35 weeks' gestation and ≥1800 g admitted with a diagnosis of Sarnat stage 1 encephalopathy. We evaluated length of hospital stay, duration of ventilation, evidence of brain injury on MRI, and neonatal morbidities. Of 1089 eligible neonates, 393 (36%) received hypothermia and 595 (55%) had neuroimaging. The hypothermia group was more likely to be outborn, born via C-section, had lower Apgar scores, and required extensive resuscitation. They had longer durations of stay (9 vs. 6 days, P < 0.001), respiratory support (3 vs. 2 days, P < 0.001), but lower odds of brain injury on MRI (adjusted odds ratio 0.33, 95% CI: 0.22-0.52) compared with standard care group. Despite prolongation of hospital stay, hypothermia may be potentially beneficial in neonates with mild HIE; however, selection bias cannot be ruled out.
Identifiants
pubmed: 31723237
doi: 10.1038/s41372-019-0551-2
pii: 10.1038/s41372-019-0551-2
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
275-283Subventions
Organisme : CIHR
ID : CTP 87518
Pays : Canada
Organisme : CIHR
ID : APR-126340
Pays : Canada
Investigateurs
Prakesh S Shah
(PS)
Jaideep Kanungo
(J)
Joseph Ting
(J)
Zenon Cieslak
(Z)
Rebecca Sherlock
(R)
Ayman Abou Mehrem
(AA)
Jennifer Toye
(J)
Carlos Fajardo
(C)
Zarin Kalapesi
(Z)
Jaya Bodani
(J)
Koravangattu Sankaran
(K)
Sibasis Daspal
(S)
Mary Seshia
(M)
Deepak Louis
(D)
Ruben Alvaro
(R)
Amit Mukerji
(A)
Orlando Da Silva
(O)
Mohammad Adie
(M)
Kyong-Soon Lee
(KS)
Michael Dunn
(M)
Brigitte Lemyre
(B)
Faiza Khurshid
(F)
Ermelinda Pelausa
(E)
Keith Barrington
(K)
Anie Lapoint
(A)
Guillaume Ethier
(G)
Christine Drolet
(C)
Bruno Piedboeuf
(B)
Martine Claveau
(M)
Marc Beltempo
(M)
Valerie Bertelle
(V)
Edith Masse
(E)
Roderick Canning
(R)
Hala Makary
(H)
Cecil Ojah
(C)
Luis Monterrosa
(L)
Julie Emberley
(J)
Jehier Afifi
(J)
Andrzej Kajetanowicz
(A)
Shoo K Lee
(SK)
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