Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics.
D. melanogaster
associative learning
cotransmitter
dopamine
memory dynamics
mushroom body
neuroscience
nitric oxide
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
14 11 2019
14 11 2019
Historique:
received:
12
06
2019
accepted:
13
11
2019
pubmed:
15
11
2019
medline:
27
5
2020
entrez:
15
11
2019
Statut:
epublish
Résumé
Animals employ diverse learning rules and synaptic plasticity dynamics to record temporal and statistical information about the world. However, the molecular mechanisms underlying this diversity are poorly understood. The anatomically defined compartments of the insect mushroom body function as parallel units of associative learning, with different learning rates, memory decay dynamics and flexibility (Aso and Rubin, 2016). Here, we show that nitric oxide (NO) acts as a neurotransmitter in a subset of dopaminergic neurons in
Identifiants
pubmed: 31724947
doi: 10.7554/eLife.49257
pii: 49257
pmc: PMC6948953
doi:
pii:
Substances chimiques
Drosophila Proteins
0
Neurotransmitter Agents
0
ppl protein, Drosophila
0
Nitric Oxide
31C4KY9ESH
Dopamine
VTD58H1Z2X
Banques de données
GEO
['GSE139889']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM084128
Pays : United States
Organisme : Simons Foundation
ID : Global Brain
Pays : International
Organisme : National Science Foundation
ID : DBI-1707398
Pays : International
Organisme : NIH HHS
ID : R01 GM84128
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : ErratumIn
Informations de copyright
© 2019, Aso et al.
Déclaration de conflit d'intérêts
YA, RR, XL, DB, KC, TN, BS, CC, AH, AL, PT, JH, AL, GR No competing interests declared
Références
Mol Cell Biochem. 1995 Aug-Sep;149-150:271-8
pubmed: 8569740
Elife. 2018 Apr 19;7:
pubmed: 29671739
Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):16080-16085
pubmed: 31337675
Cell Rep. 2012 Oct 25;2(4):991-1001
pubmed: 23063364
Nucleic Acids Res. 2019 Jan 8;47(D1):D759-D765
pubmed: 30364959
J Neurosci. 2003 Nov 19;23(33):10495-502
pubmed: 14627633
Cell Rep. 2015 May 26;11(8):1280-92
pubmed: 25981036
Nat Neurosci. 2014 Nov;17(11):1536-42
pubmed: 25262493
Cell. 2019 Jun 27;178(1):60-75.e19
pubmed: 31230716
Nat Neurosci. 2016 Dec;19(12):1697-1706
pubmed: 27694992
Neuropsychopharmacology. 2019 Feb;44(3):598-605
pubmed: 30449883
Science. 2019 Jan 18;363(6424):
pubmed: 30655415
Cell. 2009 Oct 16;139(2):405-15
pubmed: 19837039
J Neurosci. 2006 Dec 13;26(50):13037-47
pubmed: 17167093
Curr Biol. 2009 Aug 25;19(16):1341-50
pubmed: 19646879
Nat Neurosci. 2011 Jun 19;14(7):903-10
pubmed: 21685917
Nature. 2012 Dec 20;492(7429):433-7
pubmed: 23103875
Nature. 2007 Jul 12;448(7150):151-6
pubmed: 17625558
Nat Methods. 2011 Sep;8(9):737-43
pubmed: 21985007
Neuron. 2010 Feb 25;65(4):516-29
pubmed: 20188656
Neuron. 2016 Jun 15;90(6):1230-1242
pubmed: 27263975
Cell Rep. 2018 Oct 16;25(3):651-662.e5
pubmed: 30332645
Neuron. 2018 Apr 18;98(2):350-365.e5
pubmed: 29673482
eNeuro. 2015 Apr 30;2(2):
pubmed: 26464971
Curr Biol. 2010 Aug 24;20(16):1445-51
pubmed: 20637624
Genes Brain Behav. 2017 Mar;16(3):394-403
pubmed: 27762066
J Neurosci. 2007 Jul 18;27(29):7640-7
pubmed: 17634358
Nature. 2017 Aug 9;548(7666):175-182
pubmed: 28796202
Curr Biol. 2005 Nov 8;15(21):1953-60
pubmed: 16271874
Genome Biol. 2014;15(12):550
pubmed: 25516281
Nature. 2004 Aug 26;430(7003):983
pubmed: 15329711
Cell. 1994 Oct 7;79(1):35-47
pubmed: 7923375
Curr Biol. 2006 Sep 5;16(17):1741-7
pubmed: 16950113
Science. 2014 Oct 24;346(6208):1257998
pubmed: 25342811
Elife. 2014 Dec 23;3:e04577
pubmed: 25535793
Nature. 1991 Jan 24;349(6307):326-8
pubmed: 1702879
Nat Biotechnol. 2016 Sep;34(9):987-92
pubmed: 27376584
Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):198-203
pubmed: 14684832
J Neurosci. 2013 Jan 30;33(5):2166-76a
pubmed: 23365252
Nat Rev Neurosci. 2002 Feb;3(2):122-31
pubmed: 11836520
Genetics. 2015 Apr;199(4):1173-82
pubmed: 25644700
Cell. 2009 Oct 16;139(2):416-27
pubmed: 19837040
Nat Methods. 2017 Jul;14(7):703-706
pubmed: 28581495
Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):834-9
pubmed: 21187381
Cell. 2010 Feb 19;140(4):579-89
pubmed: 20178749
Neuron. 2009 Nov 25;64(4):510-21
pubmed: 19945393
Ann N Y Acad Sci. 1991;627:124-49
pubmed: 1679307
Neuron. 2012 May 10;74(3):530-42
pubmed: 22578504
J Biol Chem. 2001 Nov 9;276(45):42241-51
pubmed: 11526108
J Comp Physiol A. 1985 Sep;157(2):263-77
pubmed: 3939242
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Cell. 2016 Jan 14;164(1-2):170-182
pubmed: 26771490
Curr Biol. 2014 Apr 14;24(8):822-31
pubmed: 24684937
Science. 2001 Aug 17;293(5533):1330-3
pubmed: 11397912
Proc Natl Acad Sci U S A. 2013 May 7;110(19):7898-903
pubmed: 23610406
J Insect Sci. 2005;5:12
pubmed: 16341244
Cell. 2015 Dec 17;163(7):1742-55
pubmed: 26687359
Nat Methods. 2011 May;8(5):405-7
pubmed: 21460824
Cell. 2018 Jul 12;174(2):481-496.e19
pubmed: 30007419
Cell Rep. 2013 Nov 14;5(3):769-80
pubmed: 24209748
Genetics. 2019 Feb;211(2):473-482
pubmed: 30563859
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):578-83
pubmed: 25548178
Front Neural Circuits. 2009 Jul 01;3:5
pubmed: 19597562
Curr Biol. 2015 Mar 16;25(6):751-758
pubmed: 25728694
Learn Mem. 1998 Mar-Apr;4(6):496-509
pubmed: 10701874
Elife. 2017 Jul 18;6:
pubmed: 28718765
Front Pharmacol. 2014 Apr 02;5:56
pubmed: 24765076
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10769-72
pubmed: 7504282
Nature. 2001 May 24;411(6836):476-80
pubmed: 11373680
J Comp Neurol. 2008 Jun 10;508(5):711-55
pubmed: 18395827
BMC Bioinformatics. 2011 Aug 04;12:323
pubmed: 21816040
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8389-93
pubmed: 12048250
IEEE Pac Vis Symp. 2012;:201-208
pubmed: 23584131
J Neurosci. 2007 Oct 24;27(43):11736-47
pubmed: 17959815
Cell. 2009 Oct 2;139(1):186-98
pubmed: 19804763
J Physiol. 1969 Jun;202(2):437-70
pubmed: 5784296
Curr Biol. 2012 Nov 6;22(21):1981-9
pubmed: 23063437
Arthropod Struct Dev. 2011 Jul;40(4):368-79
pubmed: 21371566
Curr Biol. 2010 Feb 23;20(4):R141-2
pubmed: 20178753
Nat Commun. 2016 Feb 04;7:10623
pubmed: 26842907
Proc Natl Acad Sci U S A. 1983 Mar;80(5):1482-6
pubmed: 6572401
Curr Biol. 2014 Aug 4;24(15):1723-30
pubmed: 25042590
Neuron. 2015 Dec 2;88(5):985-998
pubmed: 26637800
Curr Biol. 2014 Aug 4;24(15):1712-22
pubmed: 25042591
Nature. 2012 Jan 25;482(7383):47-52
pubmed: 22278062
Neuron. 1993 Aug;11(2):197-208
pubmed: 8352940
Science. 2003 Dec 5;302(5651):1765-8
pubmed: 14657498
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Curr Biol. 2015 Nov 16;25(22):2915-27
pubmed: 26455303
Prog Neurobiol. 2005 Aug;76(5):328-47
pubmed: 16266778
Proc Natl Acad Sci U S A. 1995 Sep 26;92(20):9072-6
pubmed: 7568075
Neuron. 2015 Apr 22;86(2):417-27
pubmed: 25864636
Science. 2004 May 14;304(5673):1024-7
pubmed: 15143285
J Neurosci. 2015 May 13;35(19):7487-502
pubmed: 25972175
Nat Neurosci. 2014 Dec;17(12):1644-54
pubmed: 25413091
Nat Rev Neurosci. 2007 May;8(5):341-54
pubmed: 17453015
Cell Rep. 2018 Dec 4;25(10):2716-2728.e3
pubmed: 30517860
Cell Rep. 2015 Jun 30;11(12):1953-65
pubmed: 26095367
J Biol Chem. 1995 Jun 23;270(25):15368-76
pubmed: 7797526
Nature. 2012 Oct 11;490(7419):262-6
pubmed: 23034651
Elife. 2020 Jan 15;9:
pubmed: 31939737
J Neurosci. 2010 Jun 16;30(24):8229-33
pubmed: 20554874
J Insect Physiol. 2015 Jul;78:26-32
pubmed: 25934217
J Neurosci. 2011 Mar 2;31(9):3453-8
pubmed: 21368057
Nat Rev Neurosci. 2017 Jul;18(7):389-403
pubmed: 28592905
Cell. 2017 May 18;169(5):956-969.e17
pubmed: 28502772
Curr Biol. 2012 Apr 10;22(7):608-14
pubmed: 22425153
Neuron. 1996 Jun;16(6):1127-35
pubmed: 8663989
Neuron. 2005 Feb 17;45(4):599-611
pubmed: 15721245
Nat Rev Neurosci. 2003 Apr;4(4):266-75
pubmed: 12671643
Curr Biol. 2017 Mar 6;27(5):613-623
pubmed: 28216314
J Neurosci. 2011 Apr 13;31(15):5643-7
pubmed: 21490205
Learn Mem. 2006 Sep-Oct;13(5):659-68
pubmed: 16980542
Cell Rep. 2014 Nov 6;9(3):930-43
pubmed: 25437550
Science. 2015 Jan 30;347(6221):543-8
pubmed: 25592419
Elife. 2016 Jul 21;5:
pubmed: 27441388
Elife. 2015 Nov 17;4:e10719
pubmed: 26573957
J Neurosci. 2015 Apr 15;35(15):5950-8
pubmed: 25878268
J Neurophysiol. 2008 Mar;99(3):1559-64
pubmed: 18216231
Science. 2000 Apr 28;288(5466):672-5
pubmed: 10784450
J Neurosci. 2013 Jun 5;33(23):9846-54
pubmed: 23739981
Science. 2018 Jun 29;360(6396):
pubmed: 29853555
Neurobiol Learn Mem. 2002 Mar;77(2):125-84
pubmed: 11848717
Elife. 2014 Dec 23;3:e04580
pubmed: 25535794
Sci Rep. 2017 Aug 2;7(1):7112
pubmed: 28769066
PLoS Genet. 2012;8(7):e1002768
pubmed: 22807684
Nature. 2012 Aug 23;488(7412):512-6
pubmed: 22810589
Curr Biol. 2011 Oct 11;21(19):1647-53
pubmed: 21962716
Neuron. 2017 Mar 22;93(6):1315-1324.e3
pubmed: 28285819
Proc Natl Acad Sci U S A. 1974 Mar;71(3):708-12
pubmed: 4207071
PLoS Comput Biol. 2013;9(7):e1003146
pubmed: 23935470
Nat Neurosci. 2012 Feb 26;15(4):592-9
pubmed: 22366756
Front Syst Neurosci. 2017 Oct 16;11:76
pubmed: 29085286
J Neurosci. 2010 May 19;30(20):7105-10
pubmed: 20484653
Nature. 1990 Oct 25;347(6295):768-70
pubmed: 1700301
Science. 1994 Feb 4;263(5147):692-5
pubmed: 8303280
J Neurosci. 1998 Jun 15;18(12):4588-602
pubmed: 9614234