Neuropsychiatric aspects of Parkinson disease psychopharmacology: Insights from circuit dynamics.
Anxiety
Apathy
Circuit
Depression
Impulse control
Parkinson disease
Psychopharmacology
Psychosis
RDoC
Journal
Handbook of clinical neurology
ISSN: 0072-9752
Titre abrégé: Handb Clin Neurol
Pays: Netherlands
ID NLM: 0166161
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
16
11
2019
pubmed:
16
11
2019
medline:
18
4
2020
Statut:
ppublish
Résumé
Parkinson disease (PD) is a neurodegenerative disorder with a complex pathophysiology characterized by the progressive loss of dopaminergic neurons within the substantia nigra. Persons with PD experience several motoric and neuropsychiatric symptoms. Neuropsychiatric features of PD include depression, anxiety, psychosis, impulse control disorders, and apathy. In this chapter, we will utilize the National Institutes of Mental Health Research Domain Criteria (RDoC) to frame and integrate observations from two prevailing disease constructions: neurotransmitter anomalies and circuit physiology. When there is available evidence, we posit how unified translational observations may have clinical relevance and postulate importance outside of PD. Finally, we review the limited evidence available for pharmacologic management of these symptoms.
Identifiants
pubmed: 31727232
pii: B978-0-444-64012-3.00007-1
doi: 10.1016/B978-0-444-64012-3.00007-1
pii:
doi:
Substances chimiques
Adrenergic Uptake Inhibitors
0
Antiparkinson Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-121Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.