Relationship between metformin and abdominal aortic aneurysm.

Aortic Aneurysm, Abdominal / drug therapy Humans Hypoglycemic Agents / therapeutic use Metformin / therapeutic use
Abdominal aortic aneurysm Antidiabetic drug Biguanide Clinical trial Metformin

Journal

Journal of vascular surgery
ISSN: 1097-6809
Titre abrégé: J Vasc Surg
Pays: United States
ID NLM: 8407742

Informations de publication

Date de publication:
03 2020
Historique:
received: 21 04 2019
accepted: 20 08 2019
pubmed: 16 11 2019
medline: 30 7 2020
entrez: 16 11 2019
Statut: ppublish

Résumé

Abdominal aortic aneurysm (AAA) is a life-threatening disease and pharmacologic agents to treat the disease remain lacking for clinical practice. Epidemiologic studies have highlighted a negative association between the use of antidiabetic drugs, including metformin, and AAA. Metformin is well-known for its blood glucose-lowering effect, but its action on both metabolism and inflammatory response has led to propose it as a potential therapeutic target in several cardiovascular diseases. In this review, we summarize the current knowledge on the link between metformin and AAA. Based on the known effects of the drug on the aortic wall, translational applications and clinical trials investigating the interest of metformin in the management of patients with AAA are discussed.

Identifiants

DOI: 10.1016/j.jvs.2019.08.270 PMID: 31727461
pubmed: 31727461
pii: S0741-5214(19)32357-2
doi: 10.1016/j.jvs.2019.08.270
pii:
doi:

Substances chimiques

Hypoglycemic Agents 0
Metformin 9100L32L2N

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1056-1062

Informations de copyright

Copyright © 2019 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Auteurs

Juliette Raffort (J)

Department of Clinical Biochemistry, University Hospital of Nice, Nice, France; Université Côte d'Azur, CHU, Inserm, C3M, Nice, France. Electronic address: raffort.j@chu-nice.fr.

Réda Hassen-Khodja (R)

Université Côte d'Azur, CHU, Inserm, C3M, Nice, France; Department of Vascular Surgery, University Hospital of Nice, Nice, France.

Elixène Jean-Baptiste (E)

Université Côte d'Azur, CHU, Inserm, C3M, Nice, France; Department of Vascular Surgery, University Hospital of Nice, Nice, France.

Fabien Lareyre (F)

Université Côte d'Azur, CHU, Inserm, C3M, Nice, France; Department of Vascular Surgery, University Hospital of Nice, Nice, France.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Maladies de l'aorte › Anévrysme de l'aorte › Anévrysme de l'aorte abdominale › Relationship between metformin and abdominal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Relationship between metformin and abdominal...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Relationship between metformin and abdominal...
questionsmedicales.fr › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Relationship between metformin and abdominal...