Study on the RBE estimation for carbon beam scanning irradiation using a solid-state microdosimeter.
Carbon
/ chemistry
Computer Simulation
Dose-Response Relationship, Radiation
Heavy Ion Radiotherapy
/ methods
Humans
Kinetics
Phantoms, Imaging
Quality Assurance, Health Care
Radiation Dosimeters
Radiotherapy Planning, Computer-Assisted
Relative Biological Effectiveness
Reproducibility of Results
Semiconductors
Silicon
/ chemistry
Surface Properties
LET measurement
RBE prediction
SOI detector
carbon scanning beam
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
04
12
2018
revised:
07
11
2019
accepted:
07
11
2019
pubmed:
17
11
2019
medline:
24
11
2020
entrez:
17
11
2019
Statut:
ppublish
Résumé
The purpose of this study was to study the field size effect on the estimated Relative Biological Effectiveness (RBE) for carbon scanning beam irradiation. A silicon-on-insulator (SOI) microdosimeter system developed by the Centre for Medical Radiation Physics, University of Wollongong, Australia, was used for lineal-energy measurements (microdosimetric quantity). The RBE values were derived based on the modified microdosimetric kinetic model (MKM) at different depths in a water phantom in the scanning carbon beam for various scanned areas. Our study shows that the difference in RBE values derived from the SOI microdosimeter measurements with the MKM model and from the Treatment Planning System (TPS). The difference of the RBE values is within 6.5 % at the peak point of the spread-out Bragg Peak (SOBP) region. Compared to the spot-beam, RBE values obtained in the scanned-beam with a larger scanned area of 1.0 × 1.0 cm This study shows the possibility of using the SOI microdosimeter system as a quality assurance (QA) tool for RBE evaluation in carbon-pencil beam scanning radiotherapy.
Substances chimiques
Carbon
7440-44-0
Silicon
Z4152N8IUI
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-370Subventions
Organisme : Creative Allied Project
ID : CAP-15-06-
Organisme : Creative Allied Project
ID : ETRI
Organisme : National Research Council of Science & Technology
Informations de copyright
© 2019 American Association of Physicists in Medicine.
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