Recent Efforts to Dissect the Genetic Basis of Alcohol Use and Abuse.
AUDIT
Alcohol consumption
Alcohol-metabolizing genes
Alcoholism
Genetics
Genome-wide association studies
Journal
Biological psychiatry
ISSN: 1873-2402
Titre abrégé: Biol Psychiatry
Pays: United States
ID NLM: 0213264
Informations de publication
Date de publication:
01 04 2020
01 04 2020
Historique:
received:
21
05
2019
revised:
14
08
2019
accepted:
13
09
2019
pubmed:
18
11
2019
medline:
7
1
2021
entrez:
18
11
2019
Statut:
ppublish
Résumé
Alcohol use disorder (AUD) is defined by several symptom criteria, which can be dissected further at the genetic level. Over the past several years, our understanding of the genetic factors influencing alcohol use and abuse has progressed tremendously; numerous loci have been implicated in different aspects of alcohol use. Previously known associations with alcohol-metabolizing enzymes (ADH1B, ALDH2) have been replicated definitively. In addition, novel associations with loci containing the genes KLB, GCKR, CRHR1, and CADM2 have been reported. Downstream analyses have leveraged these genetic findings to reveal important relationships between alcohol use behaviors and both physical and mental health. AUD and aspects of alcohol misuse have been shown to overlap strongly with psychiatric disorders, whereas aspects of alcohol consumption have shown stronger links to metabolism. These results demonstrate that the genetic architecture of alcohol consumption only partially overlaps with the genetics of clinically defined AUD. We discuss the limitations of using quantitative measures of alcohol use as proxy measures for AUD, and we outline how future studies will require careful phenotype harmonization to properly capture the genetic liability to AUD.
Identifiants
pubmed: 31733789
pii: S0006-3223(19)31711-1
doi: 10.1016/j.biopsych.2019.09.011
pmc: PMC7071963
mid: NIHMS1550121
pii:
doi:
Substances chimiques
Ethanol
3K9958V90M
ADH1B protein, human
EC 1.1.1.1
Alcohol Dehydrogenase
EC 1.1.1.1
ALDH2 protein, human
EC 1.2.1.3
Aldehyde Dehydrogenase, Mitochondrial
EC 1.2.1.3
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
609-618Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIDA NIH HHS
ID : P50 DA037844
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA026281
Pays : United States
Organisme : NIMH NIH HHS
ID : R25 MH081482
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.
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