Control of Lymphocyte Fate, Infection, and Tumor Immunity by TCF-1.
T cell
T cell factor-1
TCF-1
immunotherapy
innate lymphoid cell
stem cell-like memory
transcription factor
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
07
2019
revised:
13
10
2019
accepted:
16
10
2019
pubmed:
18
11
2019
medline:
24
7
2020
entrez:
18
11
2019
Statut:
ppublish
Résumé
T cell factor-1 (TCF-1), encoded by Tcf7, is a transcription factor and histone deacetylase (HDAC) essential for commitment to both the T cell and the innate lymphoid cell (ILC) lineages in mammals. In this review, we discuss the multifunctional role of TCF-1 in establishing these lineages and the requirement for TCF-1 throughout lineage differentiation and maintenance of lineage stability. We highlight recent reports showing promise for TCF-1 as a novel biomarker to identify recently characterized subsets of exhausted CD8
Identifiants
pubmed: 31734149
pii: S1471-4906(19)30215-7
doi: 10.1016/j.it.2019.10.006
pii:
doi:
Substances chimiques
T Cell Transcription Factor 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1149-1162Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.