Opioid Use in Pregnancy.
Buprenorphine
/ therapeutic use
Child Development
/ drug effects
Female
Humans
Infant, Newborn
Methadone
/ therapeutic use
Neonatal Abstinence Syndrome
/ prevention & control
Opiate Substitution Treatment
Opioid-Related Disorders
/ drug therapy
Pregnancy
Pregnancy Complications
/ drug therapy
Treatment Outcome
Antenatal
Drug
Opioid
Opioids
Perinatal
Postpartum
Pregnancy
Journal
Current psychiatry reports
ISSN: 1535-1645
Titre abrégé: Curr Psychiatry Rep
Pays: United States
ID NLM: 100888960
Informations de publication
Date de publication:
16 11 2019
16 11 2019
Historique:
entrez:
18
11
2019
pubmed:
18
11
2019
medline:
29
5
2020
Statut:
epublish
Résumé
Perinatal opioid use is a major public health problem and is associated with a number of deleterious maternal and fetal effects. We review recent evidence of perinatal outcomes and treatment of opioid use disorder (OUD) during pregnancy. Opioid exposure in pregnancy is associated with multiple obstetric and neonatal adverse outcomes, with the most common being neonatal opioid withdrawal syndrome (NOWS). Treatment with buprenorphine or methadone is associated with NOWS, but neither medication appears to have significant adverse effects on early childhood development. Buprenorphine appears to be superior to methadone in terms of incidence and severity of NOWS in exposed infants. The long-term effects of opioid exposure in utero have been inconclusive, but recent longitudinal studies point to potential differences in brain morphology that may increase vulnerability to future stressors. Maintenance therapy with methadone or buprenorphine remains the standard of care for pregnant women with OUD given its consistent superiority to placebo in terms of rates of illicit drug use and pregnancy outcomes. New non-pharmacologic management options for NOWS appear promising. Future research is needed to further evaluate the effects of opioid exposure in utero and determine the optimal delivery model for maintenance therapy.
Identifiants
pubmed: 31734808
doi: 10.1007/s11920-019-1110-4
pii: 10.1007/s11920-019-1110-4
pmc: PMC10296780
mid: NIHMS1908498
doi:
Substances chimiques
Buprenorphine
40D3SCR4GZ
Methadone
UC6VBE7V1Z
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
118Subventions
Organisme : NIMH NIH HHS
ID : T32 MH018268
Pays : United States
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