The Action of TAAR1 Agonist RO5263397 on Executive Functions in Rats.
Attention
Cognitive flexibility
Impulsivity
RO5263397
Rats
TAAR1
Journal
Cellular and molecular neurobiology
ISSN: 1573-6830
Titre abrégé: Cell Mol Neurobiol
Pays: United States
ID NLM: 8200709
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
18
07
2019
accepted:
31
10
2019
pubmed:
18
11
2019
medline:
20
11
2020
entrez:
18
11
2019
Statut:
ppublish
Résumé
Trace amine-associated receptor 1 (TAAR1) is a widely recognized new perspective target for the neuropsychiatric pharmacological treatment. Despite a growing number of studies investigating TAAR1 role in the animal models of different pathologies, information of TAAR1 agonists impact on executive cognitive functions is limited. The goal of the present study was to evaluate the activity of highly selective partial TAAR1 agonist RO5263397 on various executive cognitive functions. The results of the present study demonstrated that the pretreatment with RO5263397 was able to increase attention and decrease cognitive flexibility in rats. The analysis of the RO5263397 action on impulsivity demonstrated that the TAAR1 activation failed to affect premature responding but was able to slightly modify impulsive choice. Problem solving was resistant to the pharmacological intervention.
Identifiants
pubmed: 31734895
doi: 10.1007/s10571-019-00757-6
pii: 10.1007/s10571-019-00757-6
doi:
Substances chimiques
4-(3-fluoro-2-methylphenyl)-4,5-dihydrooxazol-2-ylamine
0
Oxazoles
0
Receptors, G-Protein-Coupled
0
Trace amine-associated receptor 1
XMC8VP6RI2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
215-228Subventions
Organisme : Russian Science Foundation
ID : 17-75-20177
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