Serrated Colorectal Cancer: The Road Less Travelled?
atypical PKC
colorectal cancer
immune checkpoint therapy
mesenchymal
microenvironment
serrated
Journal
Trends in cancer
ISSN: 2405-8025
Titre abrégé: Trends Cancer
Pays: United States
ID NLM: 101665956
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
05
08
2019
revised:
09
09
2019
accepted:
10
09
2019
entrez:
19
11
2019
pubmed:
19
11
2019
medline:
17
7
2020
Statut:
ppublish
Résumé
Studies of colorectal cancer (CRC) originating through the conventional adenoma-carcinoma sequence have provided insight into the molecular mechanisms controlling its initiation and progression. Less is known about the alternative 'serrated' pathway, which has been associated with BRAF mutation and microsatellite instability. Recent transcriptomics approaches to classify human CRC revealed that mesenchymal and/or desmoplastic features combined with an immunosuppressive microenvironment are key determinants of CRC with the poorest prognosis. Importantly, these aggressive CRCs harbor the characteristics of serrated tumors, suggesting that initiation through this alternative pathway determines how aggressive the CRC becomes. Here, we review recent evidence on how serrated carcinogenesis contributes to the subtype of CRC with the poorest prognosis.
Identifiants
pubmed: 31735291
pii: S2405-8033(19)30187-6
doi: 10.1016/j.trecan.2019.09.004
pmc: PMC6894428
mid: NIHMS1544834
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
742-754Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK108743
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211794
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA207177
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192642
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA218254
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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