Parietal P3 and midfrontal theta prospectively predict the development of adolescent alcohol use.
Adolescent alcohol use
EEG/ERP
P3
endophenotype
longitudinal design
theta
Journal
Psychological medicine
ISSN: 1469-8978
Titre abrégé: Psychol Med
Pays: England
ID NLM: 1254142
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
pubmed:
19
11
2019
medline:
16
11
2021
entrez:
19
11
2019
Statut:
ppublish
Résumé
Subclinical adolescent alcohol use is highly prevalent and may have deleterious effects on important psychosocial and brain outcomes. Prior research has focused on identifying endophenotypes of pathological drinking, and the predictors of normative drinking remain understudied. This study investigated the incremental predictive value of two potential psychophysiological endophenotypes, P3 amplitude (an index of decision making) and midfrontal theta power (a correlate of attentional control), for prospectively predicting the expression and initiation of alcohol use emerging in adolescence. A large (N = 594) epidemiological sample was prospectively assessed at ages 11/14/17. Alcohol/substance use was assessed at all ages via a computerized self-report inventory. EEG was recorded at age-14 during a visual oddball task to elicit P3 and theta. Reduced target-related P3 and theta at age-14 prospectively predicted drinking at age-17 independent of one another. Among alcohol-naive individuals at age-14, attenuated P3 and theta increased the odds of new-onset alcohol behaviors 3 years later. Importantly, the endophenotypes provided significant incremental predictive power of future non-clinical alcohol use beyond relevant risk factors (prior alcohol use; tobacco/illicit drug initiation; parental alcohol use disorder). The current report is the first of our knowledge to demonstrate that deviations in parietal P3 and midfrontal theta prospectively predict the emergence of normative/non-pathological drinking. P3 and theta provide modest yet significant explanatory variance beyond prominent self-report and familial risk measures. Findings offer strong evidence supporting the predictive utility of P3 and theta as candidate endophenotypes for adolescent drinking.
Sections du résumé
BACKGROUND
Subclinical adolescent alcohol use is highly prevalent and may have deleterious effects on important psychosocial and brain outcomes. Prior research has focused on identifying endophenotypes of pathological drinking, and the predictors of normative drinking remain understudied. This study investigated the incremental predictive value of two potential psychophysiological endophenotypes, P3 amplitude (an index of decision making) and midfrontal theta power (a correlate of attentional control), for prospectively predicting the expression and initiation of alcohol use emerging in adolescence.
METHODS
A large (N = 594) epidemiological sample was prospectively assessed at ages 11/14/17. Alcohol/substance use was assessed at all ages via a computerized self-report inventory. EEG was recorded at age-14 during a visual oddball task to elicit P3 and theta.
RESULTS
Reduced target-related P3 and theta at age-14 prospectively predicted drinking at age-17 independent of one another. Among alcohol-naive individuals at age-14, attenuated P3 and theta increased the odds of new-onset alcohol behaviors 3 years later. Importantly, the endophenotypes provided significant incremental predictive power of future non-clinical alcohol use beyond relevant risk factors (prior alcohol use; tobacco/illicit drug initiation; parental alcohol use disorder).
CONCLUSIONS
The current report is the first of our knowledge to demonstrate that deviations in parietal P3 and midfrontal theta prospectively predict the emergence of normative/non-pathological drinking. P3 and theta provide modest yet significant explanatory variance beyond prominent self-report and familial risk measures. Findings offer strong evidence supporting the predictive utility of P3 and theta as candidate endophenotypes for adolescent drinking.
Identifiants
pubmed: 31736455
doi: 10.1017/S0033291719003258
pii: S0033291719003258
pmc: PMC7231637
mid: NIHMS1556779
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
416-425Subventions
Organisme : NIDA NIH HHS
ID : R01 DA013240
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA026919
Pays : United States
Références
Addiction. 2015 Feb;110(2):269-78
pubmed: 25251778
Neuropsychopharmacology. 2010 Jan;35(1):217-38
pubmed: 19710631
J Stud Alcohol Drugs. 2017 Jan;78(1):49-58
pubmed: 27936364
Trends Cogn Sci. 2014 Aug;18(8):414-21
pubmed: 24835663
Dev Psychopathol. 2004 Winter;16(1):193-213
pubmed: 15115071
Psychophysiology. 2013 Oct;50(10):974-82
pubmed: 23905780
Curr Addict Rep. 2015 Mar;2(1):76-90
pubmed: 26236574
Clin Neurophysiol. 2006 Oct;117(10):2128-43
pubmed: 16926113
Dev Psychopathol. 2018 Feb;30(1):79-92
pubmed: 28424107
Am J Psychiatry. 2014 Dec 1;171(12):1236-9
pubmed: 25756762
Psychophysiology. 2019 Aug;56(8):e13383
pubmed: 31012496
Front Psychol. 2011 Feb 28;2:30
pubmed: 21713190
Drug Alcohol Depend. 2013 Mar 1;128(3):243-9
pubmed: 23021773
Psychophysiology. 2012 Feb;49(2):220-38
pubmed: 22091878
Biol Psychiatry. 2006 Apr 1;59(7):625-34
pubmed: 16213472
Int J Psychophysiol. 2014 Aug;93(2):173-97
pubmed: 24739435
Curr Addict Rep. 2015;2(2):141-155
pubmed: 25960940
Alcohol Alcohol. 2001 Jan-Feb;36(1):85-8
pubmed: 11139422
Psychophysiology. 2004 Nov;41(6):841-4
pubmed: 15563337
Biol Psychiatry. 2009 Oct 15;66(8):750-7
pubmed: 19640504
J Stud Alcohol Drugs. 2013 Sep;74(5):703-13
pubmed: 23948529
Pharmacol Biochem Behav. 2009 Sep;93(3):237-47
pubmed: 19410598
J Abnorm Psychol. 2013 Aug;122(3):902-16
pubmed: 24016026
Sci Rep. 2016 Aug 11;6:31200
pubmed: 27510599
Nature. 2014 Aug 14;512(7513):185-9
pubmed: 25043041
Arch Gen Psychiatry. 2002 Aug;59(8):750-7
pubmed: 12150652
Clin Neurophysiol. 2014 Oct;125(10):2007-15
pubmed: 24656843
Am J Psychiatry. 2019 Jul 1;176(7):531-542
pubmed: 31014101
Child Dev Perspect. 2012 Dec 1;6(4):392-399
pubmed: 23543860
Annu Rev Clin Psychol. 2013;9:703-21
pubmed: 23245341
Trends Cogn Sci. 2015 Apr;19(4):188-95
pubmed: 25765608
Am J Psychiatry. 2018 Apr 1;175(4):370-380
pubmed: 29084454
Neuropsychol Rev. 2010 Mar;20(1):1-20
pubmed: 19685291
Annu Rev Clin Psychol. 2008;4:325-48
pubmed: 18370620
Addict Biol. 2018 Jan;23(1):256-267
pubmed: 27859998
Psychol Bull. 2005 Jul;131(4):510-32
pubmed: 16060800
Dev Cogn Neurosci. 2015 Dec;16:130-138
pubmed: 26278682
Clin Neurophysiol. 2007 Oct;118(10):2128-48
pubmed: 17573239
J Am Acad Child Adolesc Psychiatry. 2006 Apr;45(4):468-75
pubmed: 16601652
Int J Psychophysiol. 2018 Jun;128:70-80
pubmed: 29574233
Am J Psychiatry. 2015 Jun;172(6):531-42
pubmed: 25982660
Am J Psychiatry. 2003 Jun;160(6):1078-85
pubmed: 12777265
Behav Genet. 2014 Jul;44(4):407-18
pubmed: 24676464
Int J Psychophysiol. 2017 Jan;111:115-144
pubmed: 27473600
Biol Psychiatry. 1995 Jun 1;37(11):823-7
pubmed: 7647169
Twin Res Hum Genet. 2009 Oct;12(5):489-501
pubmed: 19803776
PLoS One. 2015 Nov 18;10(11):e0142659
pubmed: 26580209
Int J Psychophysiol. 1992 Sep;13(2):161-79
pubmed: 1399755
Psychophysiology. 2014 Nov;51(11):1089-100
pubmed: 24981371
Neurosci Biobehav Rev. 2012 Jan;36(1):572-603
pubmed: 21964481
Psychophysiology. 2013 Jul;50(7):595-609
pubmed: 23614581
Alcohol Clin Exp Res. 2010 Apr;34(4):669-80
pubmed: 20102573
Clin Neurophysiol. 2017 Nov;128(11):2358-2368
pubmed: 28935223
Int J Psychophysiol. 2007 Jan;63(1):3-15
pubmed: 17129626
PLoS Biol. 2004 Jun;2(6):e176
pubmed: 15208723
Psychophysiology. 2015 Dec;52(12):1632-45
pubmed: 26402396
Am J Psychiatry. 2014 Dec 1;171(12):1310-9
pubmed: 25073448
Biol Psychol. 2018 Nov;139:25-38
pubmed: 30300674
Biol Psychiatry. 2005 Jan 1;57(1):76-82
pubmed: 15607303
J Am Acad Child Adolesc Psychiatry. 2010 Dec;49(12):1189-201; quiz 1285
pubmed: 21093769
Alcohol. 1993 Jan-Feb;10(1):69-76
pubmed: 8447968
Am J Drug Alcohol Abuse. 2013 Nov;39(6):345-55
pubmed: 24200204
Psychophysiology. 2020 Jul;57(7):e13371
pubmed: 30920012
Psychol Assess. 2019 Dec;31(12):1512-1529
pubmed: 30896211
Adv Cogn Psychol. 2016 Jun 30;12(2):88-104
pubmed: 27512527
Drug Alcohol Depend. 2011 Dec 15;119(3):216-23
pubmed: 21782354
Psychol Bull. 1959 Mar;56(2):81-105
pubmed: 13634291
Psychophysiology. 2017 Nov;54(11):1590-1605
pubmed: 28580687
Science. 1984 Sep 28;225(4669):1493-6
pubmed: 6474187
Addiction. 2004 Dec;99(12):1529-41
pubmed: 15585044
Behav Genet. 2010 Mar;40(2):186-200
pubmed: 20155392
Alcohol Clin Exp Res. 2010 May;34(5):819-33
pubmed: 20184563
Curr Psychiatry Rep. 2016 May;18(5):46
pubmed: 26984684
Am J Psychiatry. 2003 Apr;160(4):636-45
pubmed: 12668349
Behav Genet. 2014 Nov;44(6):620-8
pubmed: 25224596
Psychol Addict Behav. 2014 Jun;28(2):322-35
pubmed: 24955662
Am J Psychiatry. 2019 Feb 1;176(2):119-128
pubmed: 30336705
Child Dev Perspect. 2011 Dec 1;5(4):239-247
pubmed: 22247735
Trends Neurosci. 2014 Sep;37(9):480-90
pubmed: 25034536
Dev Psychopathol. 2004 Fall;16(4):943-66
pubmed: 15704822
Drug Alcohol Depend. 2008 Sep 1;97(1-2):1-20
pubmed: 18479844
J Neurosci. 2007 Oct 31;27(44):11949-59
pubmed: 17978035
Child Dev Perspect. 2011 Dec;5(4):248-255
pubmed: 22116786