Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction.
DNA (Cytosine-5-)-Methyltransferases
/ genetics
DNA Methylation
/ genetics
Epigenesis, Genetic
/ genetics
Face
/ abnormalities
Genome
/ genetics
Histones
/ genetics
Humans
Induced Pluripotent Stem Cells
/ metabolism
Mutation
Primary Immunodeficiency Diseases
/ genetics
Promoter Regions, Genetic
/ genetics
Telomere
/ genetics
DNA Methyltransferase 3B
DNA methylation
DNMT3B
ICF syndrome
human
human biology
medicine
regenerative medicine
stem cells
subtelomere
telomere
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
20 11 2019
20 11 2019
Historique:
received:
22
04
2019
accepted:
17
11
2019
pubmed:
19
11
2019
medline:
19
5
2020
entrez:
19
11
2019
Statut:
epublish
Résumé
DNA methyltransferase 3B (DNMT3B) is the major DNMT that methylates mammalian genomes during early development. Mutations in human
Identifiants
pubmed: 31738163
doi: 10.7554/eLife.47859
pii: 47859
pmc: PMC6897513
doi:
pii:
Substances chimiques
Histones
0
histone H3 trimethyl Lys4
0
DNA (Cytosine-5-)-Methyltransferases
EC 2.1.1.37
Banques de données
GEO
['GSE137183', 'GSE138265']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Israel Science Foundation
ID : 1362/17
Pays : International
Organisme : Telethon
ID : GGP15209
Pays : Italy
Organisme : PON/MISE
ID : 2014-2020 FESR F/050011/01-02/X32
Pays : International
Organisme : MIUR/CNR
ID : Epigenomics Flagship Project (EPIGEN)
Pays : International
Informations de copyright
© 2019, Toubiana et al.
Déclaration de conflit d'intérêts
ST, MG, MP, RM, MT, MM, SS No competing interests declared
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