The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.
antagonist
histamine H3 receptor
neuroprotection
oxidative stress
pilocarpine
rats
status epilepticus
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Nov 2019
14 Nov 2019
Historique:
received:
03
10
2019
revised:
05
11
2019
accepted:
11
11
2019
entrez:
20
11
2019
pubmed:
20
11
2019
medline:
14
4
2020
Statut:
epublish
Résumé
Epilepsy is a multifaceted neurological disorder which severely affects neuronal function. Some patients may experience status epilepticus (SE), a life-threatening state of ongoing seizure activity linked to cognitive dysfunction, necessitating an immediate intervention. The potential of histamine H3 receptors in several neuropsychiatric diseases including epilepsy is well recognized. In the current study, we aimed to explore the effect of H3R antagonist E177 on prevention and termination of pilocarpine (PLC)-induced SE in rats as well as evaluating the effects of E177 on the levels of oxidative stress in hippocampus tissues. The results showed that the survival rate of animals pretreated with E177 (5 and 10 mg/kg, intraperitoneal (i.p.)) was significantly increased during the first hour of observation, and animals were protected from SE incidence and showed a prolonged average of latency to the first seizure when compared with animals pretreated with PLC (400 mg/kg, i.p.). Moreover, the protective effect of E177 (10 mg/kg) on SE was partially reversed when rats were co- administered with H3R agonist
Identifiants
pubmed: 31739417
pii: molecules24224106
doi: 10.3390/molecules24224106
pmc: PMC6891424
pii:
doi:
Substances chimiques
Histamine H3 Antagonists
0
Neuroprotective Agents
0
Pilocarpine
01MI4Q9DI3
Catalase
EC 1.11.1.6
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : College of Medicine and Health Sciences, United Arab Emirates University
ID : 31M310
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