Splenic infarction associated with transient anti-prothrombin antibodies is a rare manifestation of acute Mycoplasma pneumoniae infection.

Antiphospholipid antibodies Mycoplasma pneumoniae Splenic infarction Thrombosis anti-prothrombin antibodies

Journal

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
ISSN: 1769-664X
Titre abrégé: Arch Pediatr
Pays: France
ID NLM: 9421356

Informations de publication

Date de publication:
Nov 2019
Historique:
received: 11 04 2019
revised: 29 08 2019
accepted: 06 10 2019
pubmed: 20 11 2019
medline: 1 5 2020
entrez: 20 11 2019
Statut: ppublish

Résumé

We report the first paediatric case of splenic infarction following acute Mycoplasma pneumoniae infection with induction of anti-prothrombin (aPT) antibodies. A 12-year-old boy was admitted to the paediatric emergency department for a left pleuropneumonia and a splenic infarction. aPT antibodies were transitorily detected. The patient recovered fully after antibiotic therapy and a 3-month course of anticoagulation treatment. Antiphospholipid (aPL) antibodies induced by acute infections have already been reported but cases of clinically relevant thrombosis remain rare. The pathogenicity of aPT antibodies is discussed here. We hypothesize that these antibodies were involved in this symptomatic hypercoagulable state.

Identifiants

pubmed: 31740285
pii: S0929-693X(19)30150-2
doi: 10.1016/j.arcped.2019.10.001
pii:
doi:

Substances chimiques

Autoantibodies 0
Prothrombin 9001-26-7

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

483-486

Informations de copyright

Copyright © 2019. Published by Elsevier Masson SAS.

Auteurs

A Pachet (A)

Service de réanimation et de surveillance continue pédiatrique, Hôpital Couple Enfant, CHU de Grenoble Alpes, 38000 Grenoble, France. Electronic address: apachet@chu-grenoble.fr.

C Dumestre-Perard (C)

Laboratoire d'Immunologie, CHU de Grenoble Alpes, 38000 Grenoble, France; BNI TIMC-IMAG, UMR5525, CNRS-Université Grenoble Alpes, 38000 Grenoble, France.

M Moine (M)

Service de réanimation et de surveillance continue pédiatrique, Hôpital Couple Enfant, CHU de Grenoble Alpes, 38000 Grenoble, France.

R Marlu (R)

Laboratoire d'Hémostase, CHU de Grenoble Alpes, 38000 Grenoble, France.

A Rubio (A)

Service des Pédiatries de Spécialité, Hôpital Couple Enfants, CHU de Grenoble Alpes, 38000 Grenoble, France; Université Grenoble Alpes, 38000 Grenoble; Antenne pédiatrique du CIC du CHU de Grenoble Alpes - Unité INSERM CIC1406, 38000 Grenoble, France.

C Bost-Bru (C)

Service de pédiatrie générale, Hôpital Couple Enfant, CHU de Grenoble Alpes, 38000 Grenoble, France.

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Classifications MeSH