Prevalence, type distribution and risk factors for oral HPV in Danish renal transplant recipients.
human papillomavirus
oral
prevalence
renal transplant recipients
risk
Journal
Oral diseases
ISSN: 1601-0825
Titre abrégé: Oral Dis
Pays: Denmark
ID NLM: 9508565
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
12
11
2019
accepted:
12
11
2019
pubmed:
20
11
2019
medline:
10
3
2020
entrez:
20
11
2019
Statut:
ppublish
Résumé
To assess the prevalence and type distribution of oral human papillomavirus (HPV) among renal transplant recipients (RTRs) and healthy controls and to examine risk factors for oral HPV among RTRs. During 2016-2017 we recruited 250 RTRs and 250 controls. Oral samples were tested for HPV DNA with INNO-LiPA HPV Genotyping Extra II. All participants answered a questionnaire on lifestyle and sexual behaviour, and characteristics of RTRs were obtained from medical files. We assessed prevalence and type distribution of oral HPV. Using logistic regression, the risk of oral HPV and risk factors for oral HPV among RTRs were estimated as odds ratios (OR) with 95% confidence intervals (CI). Overall, 30 RTRs (12.1%) and 26 controls (10.4%) were oral HPV positive (OR = 1.14; 95% CI: 0.64-2.05). Female RTRs tended to have a higher oral HPV prevalence than controls (OR = 1.73; 95% CI: 0.63-4.77), while no difference was observed among men. HPV51 was the commonest genotype. Sexual behaviour tended to be associated with oral HPV among RTRs. There was no overall difference in oral HPV prevalence between RTRs and controls, but female RTRs tended to have a higher prevalence of oral HPV than controls.
Types de publication
Journal Article
Langues
eng
Pagination
484-488Subventions
Organisme : The Danish Kidney Association Research Foundation
Organisme : The Danish Cancer Society
ID : R134-A8560
Organisme : The Aage Bang Foundation
Organisme : The Arvid Nilsson Foundation
Organisme : The Johannes Clemmensen Foundation
Organisme : The Grosserer L.F. Foght Foundation
Organisme : The Danish Dermatological Society Research Foundation
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved.
Références
Ammatuna, P., Campisi, G., Giovannelli, L., Giambelluca, D., Alaimo, C., Mancuso, S., & Maegiotta, V. (2001). Presence of Epstein-Barr virus, cytomegalovirus and human papillomavirus in normal oral mucosa of HIV-infected and renal transplant patients. Oral Diseases, 7, 34-40.
Bihl, M. P., Tornillo, L., Kind, A. B., Obermann, E., Noppen, C., Chaffard, R., … Hoeller, S. (2017). Human papillomavirus (HPV) detection in cytologic specimens: Similarities and differences of available methodology. Applied Immunohistochemistry & Molecular Morphology, 25, 184-189. https://doi.org/10.1097/pai.0000000000000290
Bouvard, V., Baan, R., Straif, K., Grosse, Y., Secretan, B., Ghissassi, F. E., … Cogliano, V. (2009). A review of human carcinogens - Part B: Biological agents. The Lancet Oncology, 10, 321-322. https://doi.org/10.1016/S1470-2045(09)70096-8
Krynitz, B., Edgren, G., Lindelöf, B., Baecklund, E., Brattström, C., Wilczek, H., & Smedby, K. E. (2012). Risk of skin cancer and other malignancies in kidney, liver, heart and lung transplant recipients 1970 to 2008 - A Swedish population-based study. International Journal of Cancer, 132, 1429-1438. https://doi.org/10.1002/ijc.27765
Le, J. (2016). Oncogenic γ Herpesviruses EBV and HHV8 in kidney transplantation. Seminars in Nephrology, 36, 362-371. https://doi.org/10.1016/j.semnephrol.2016.05.013
Ndiaye, C., Mena, M., Alemany, L., Arbyn, M., Castellsagué, X., Laporte, L., … Trottier, H. (2014). HPV DNA, E6/E7 mRNA and p16INK4a detection in head and neck cancers: A systematic review and meta-analysis. The Lancet Oncology, 15, 1319-1331. https://doi.org/10.1016/S1470-2045(14)70471-1
Rose, B., Wilkins, D., Li, W., Tran, N., Thompson, C., Cossart, Y., … Eris, J. (2006). Human papillomavirus in the oral cavity of patients with and without renal transplantation. Transplantation, 82, 570-573. https://doi.org/10.1097/01.tp.0000231706.79165.e5
Szubińska-Lelonkiewicz, D., Osiak, M., Wychowański, P., Siewert-Gutowska, M., & Fiedor, P. (2018). Frequency of human papilloma virus occurrence among pathological changes of the oral cavity in kidney allotransplant recipients undergoing long-term pharmacological immunosuppressive therapy. Transplantation Proceedings, 50, 1878-1880. https://doi.org/10.1016/j.transproceed.2018.05.008