Androgen-Regulated microRNAs (AndroMiRs) as Novel Players in Adipogenesis.
adipogenesis
androgens
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Nov 2019
16 Nov 2019
Historique:
received:
01
11
2019
revised:
11
11
2019
accepted:
12
11
2019
entrez:
21
11
2019
pubmed:
21
11
2019
medline:
4
4
2020
Statut:
epublish
Résumé
The development, homeostasis, or increase of the adipose tissue is driven by the induction of the adipogenic differentiation (adipogenesis) of undifferentiated mesenchymal stem cells (MSCs). Adipogenesis can be inhibited by androgen stimulation of these MSCs resulting in the transcription initiation or repression of androgen receptor (AR) regulated genes. AR not only regulates the transcription of protein-coding genes but also the transcription of several non-coding microRNAs involved in the posttranscriptional gene regulation (herein designated as AndroMiRs). As microRNAs are largely involved in differentiation processes such as adipogenesis, the involvement of AndroMiRs in the androgen-mediated inhibition of adipogenesis is likely, however, not yet intensively studied. In this review, existing knowledge about adipogenesis-related microRNAs and AndroMiRs is summarized, and putative cross-links are drawn, which are still prone to experimental validation.
Identifiants
pubmed: 31744106
pii: ijms20225767
doi: 10.3390/ijms20225767
pmc: PMC6888160
pii:
doi:
Substances chimiques
Androgens
0
MicroRNAs
0
Receptors, Androgen
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : GR-4469/1
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