Protecting-Group-Free Formal Synthesis of Aspidospermidine: Ring-Opening Cyclization of Spirocyclopropane with Amine Followed by Regioselective Alkylations.


Journal

The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R

Informations de publication

Date de publication:
20 12 2019
Historique:
pubmed: 21 11 2019
medline: 26 8 2020
entrez: 21 11 2019
Statut: ppublish

Résumé

A concise formal synthesis of (±)-aspidospermidine via Stork's intermediate, which could be used as a divergent synthesis of

Identifiants

pubmed: 31746202
doi: 10.1021/acs.joc.9b02469
doi:

Substances chimiques

Amines 0
Indole Alkaloids 0
Quinolines 0
aspidospermidine 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

15990-15996

Auteurs

Hisanori Nambu (H)

Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Sugitani, Toyama 930-0194 , Japan.

Takafumi Tamura (T)

Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Sugitani, Toyama 930-0194 , Japan.

Takayuki Yakura (T)

Graduate School of Medicine and Pharmaceutical Sciences , University of Toyama , Sugitani, Toyama 930-0194 , Japan.

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Classifications MeSH