Subcortical surface morphometry in substance dependence: An ENIGMA addiction working group study.
Adolescent
Adult
Brain
/ diagnostic imaging
Cannabis
/ adverse effects
Cocaine
/ adverse effects
Ethanol
/ adverse effects
Female
Humans
Magnetic Resonance Imaging
Male
Methamphetamine
/ adverse effects
Neuroimaging
Nicotine
/ adverse effects
Substance-Related Disorders
/ diagnostic imaging
Young Adult
addiction
structural MRI
substance dependence
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
17
04
2019
revised:
25
07
2019
accepted:
26
08
2019
pubmed:
21
11
2019
medline:
29
9
2021
entrez:
21
11
2019
Statut:
ppublish
Résumé
While imaging studies have demonstrated volumetric differences in subcortical structures associated with dependence on various abused substances, findings to date have not been wholly consistent. Moreover, most studies have not compared brain morphology across those dependent on different substances of abuse to identify substance-specific and substance-general dependence effects. By pooling large multinational datasets from 33 imaging sites, this study examined subcortical surface morphology in 1628 nondependent controls and 2277 individuals with dependence on alcohol, nicotine, cocaine, methamphetamine, and/or cannabis. Subcortical structures were defined by FreeSurfer segmentation and converted to a mesh surface to extract two vertex-level metrics-the radial distance (RD) of the structure surface from a medial curve and the log of the Jacobian determinant (JD)-that, respectively, describe local thickness and surface area dilation/contraction. Mega-analyses were performed on measures of RD and JD to test for the main effect of substance dependence, controlling for age, sex, intracranial volume, and imaging site. Widespread differences between dependent users and nondependent controls were found across subcortical structures, driven primarily by users dependent on alcohol. Alcohol dependence was associated with localized lower RD and JD across most structures, with the strongest effects in the hippocampus, thalamus, putamen, and amygdala. Meanwhile, nicotine use was associated with greater RD and JD relative to nonsmokers in multiple regions, with the strongest effects in the bilateral hippocampus and right nucleus accumbens. By demonstrating subcortical morphological differences unique to alcohol and nicotine use, rather than dependence across all substances, results suggest substance-specific relationships with subcortical brain structures.
Identifiants
pubmed: 31746534
doi: 10.1111/adb.12830
pmc: PMC7237314
mid: NIHMS1048424
doi:
Substances chimiques
Ethanol
3K9958V90M
Methamphetamine
44RAL3456C
Nicotine
6M3C89ZY6R
Cocaine
I5Y540LHVR
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12830Subventions
Organisme : NIDA NIH HHS
ID : R01 DA014100
Pays : United States
Organisme : NCRR NIH HHS
ID : UL1 RR024925
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH017140
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIDA NIH HHS
ID : PL1 DA024859
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG058507
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIAAA NIH HHS
ID : L30 AA024302
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA020709
Pays : United States
Organisme : NIAAA NIH HHS
ID : RC1 AA019036
Pays : United States
Organisme : NIDA NIH HHS
ID : RL1 DA024853
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA AA000123
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA013892
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH073526
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA015179
Pays : United States
Organisme : NCRR NIH HHS
ID : M01 RR000865
Pays : United States
Organisme : NIDA NIH HHS
ID : P20 DA022539
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA016599
Pays : United States
Organisme : NIDA NIH HHS
ID : K25 DA040032
Pays : United States
Organisme : NIAAA NIH HHS
ID : R01 AA021449
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA023248
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA047119
Pays : United States
Organisme : NIAAA NIH HHS
ID : R00 AA025401
Pays : United States
Organisme : CIHR
Pays : Canada
Organisme : NIDA NIH HHS
ID : F30 DA021961
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA018307
Pays : United States
Informations de copyright
© 2019 Society for the Study of Addiction.
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