5-HT2AR and BDNF gene variants in eating disorders susceptibility.
Adolescent
Adult
Brain-Derived Neurotrophic Factor
/ genetics
DNA Methylation
Family Health
Feeding and Eating Disorders
/ genetics
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Italy
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Receptor, Serotonin, 5-HT2A
/ genetics
Young Adult
5-HT2AR
BDNF
anorexia nervosa
binge eating
bulimia nervosa
Journal
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
ISSN: 1552-485X
Titre abrégé: Am J Med Genet B Neuropsychiatr Genet
Pays: United States
ID NLM: 101235742
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
13
03
2019
revised:
09
09
2019
accepted:
01
11
2019
pubmed:
21
11
2019
medline:
18
2
2021
entrez:
21
11
2019
Statut:
ppublish
Résumé
Evidence from family and twin studies points to a genetic contribution to the etiology of eating disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (SNPs) with this group of disorders. Previous reports have suggested that the serotonin receptor (5-HT2AR) and brain-derived neurotrophic factor (BDNF) genes could be both involved in EDs susceptibility. In order to provide further evidence about such association, we focused our attention on two SNPs located in these genes carrying out a genetic association study on a large Italian cohort composed of 556 ED patients and 355 controls (CTRs). Obtained results confirm the presence of an association between 5-HT2AR and BDNF genes and the susceptibility to EDs.
Identifiants
pubmed: 31746551
doi: 10.1002/ajmg.b.32771
doi:
Substances chimiques
Brain-Derived Neurotrophic Factor
0
HTR2A protein, human
0
Receptor, Serotonin, 5-HT2A
0
BDNF protein, human
7171WSG8A2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
155-163Informations de copyright
© 2019 Wiley Periodicals, Inc.
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