Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria.

Animals Antibody Affinity / genetics B-Lymphocytes / metabolism Germinal Center / cytology Malaria / immunology Mice Mice, Inbred C57BL Mutation / genetics RGS Proteins / genetics Receptors, CXCR3 / genetics T-Box Domain Proteins / genetics
B cells T-bet affinity maturation antibodies germinal center malaria

Journal

Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691

Informations de publication

Date de publication:
19 11 2019
Historique:
received: 09 10 2018
revised: 06 06 2019
accepted: 22 10 2019
entrez: 21 11 2019
pubmed: 21 11 2019
medline: 22 9 2020
Statut: ppublish

Résumé

Despite the key role that antibodies play in protection, the cellular processes mediating the acquisition of humoral immunity against malaria are not fully understood. Using an infection model of severe malaria, we find that germinal center (GC) B cells upregulate the transcription factor T-bet during infection. Molecular and cellular analyses reveal that T-bet in B cells is required not only for IgG

Identifiants

DOI: 10.1016/j.celrep.2019.10.087 PMID: 31747599
pubmed: 31747599
pii: S2211-1247(19)31409-3
doi: 10.1016/j.celrep.2019.10.087
pii:
doi:

Substances chimiques

RGS Proteins 0
Receptors, CXCR3 0
T-Box Domain Proteins 0
T-box transcription factor TBX21 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2257-2269.e6

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Ann Ly (A)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Yang Liao (Y)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Halina Pietrzak (H)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Lisa J Ioannidis (LJ)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Tom Sidwell (T)

The University of Melbourne, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.

Renee Gloury (R)

The University of Melbourne, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia.

Marcel Doerflinger (M)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Tony Triglia (T)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Raymond Z Qin (RZ)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Joanna R Groom (JR)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Gabrielle T Belz (GT)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia.

Kim L Good-Jacobson (KL)

Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia; Infection and Immunity Program, Biomedicine Discovery Institute, Monash University, Clayton, Victoria 3800, Australia.

Wei Shi (W)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Computing and Information Systems, The University of Melbourne, Parkville, Victoria 3010, Australia.

Axel Kallies (A)

The University of Melbourne, Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, 792 Elizabeth Street, Melbourne, Victoria 3000, Australia. Electronic address: axel.kallies@unimelb.edu.au.

Diana S Hansen (DS)

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, Victoria 3010, Australia. Electronic address: hansen@wehi.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Affinité des anticorps › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Protéines d'activation de la GTPase › Protéines RGS › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CXCR › Récepteurs CXCR3 › Transcription Factor T-bet in B Cells...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Protéines à domaine boîte-T › Transcription Factor T-bet in B Cells...