A new antibiotic selectively kills Gram-negative pathogens.
Animals
Anti-Bacterial Agents
/ chemistry
Bacterial Outer Membrane Proteins
/ antagonists & inhibitors
Cell Line
Disease Models, Animal
Drug Discovery
Drug Resistance, Microbial
/ drug effects
Escherichia coli Proteins
/ antagonists & inhibitors
Female
Gastrointestinal Microbiome
/ drug effects
Gram-Negative Bacteria
/ drug effects
Humans
Mice
Microbial Sensitivity Tests
Microbial Viability
/ drug effects
Mutation
Nematoda
/ microbiology
Operon
/ genetics
Phenylpropionates
/ isolation & purification
Photorhabdus
/ chemistry
Substrate Specificity
Symbiosis
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
03
04
2019
accepted:
08
11
2019
pubmed:
21
11
2019
medline:
28
4
2020
entrez:
21
11
2019
Statut:
ppublish
Résumé
The current need for novel antibiotics is especially acute for drug-resistant Gram-negative pathogens
Identifiants
pubmed: 31747680
doi: 10.1038/s41586-019-1791-1
pii: 10.1038/s41586-019-1791-1
pmc: PMC7188312
mid: NIHMS1542542
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Outer Membrane Proteins
0
BamA protein, E coli
0
Escherichia coli Proteins
0
Phenylpropionates
0
darobactin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
459-464Subventions
Organisme : NIH HHS
ID : GM127884
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127896
Pays : United States
Organisme : NIH HHS
ID : GM127896
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI118687
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127884
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : ErratumIn
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