Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency
Amino Acids
/ genetics
Animals
Cell Line
Cell Line, Tumor
Female
Genetic Variation
/ genetics
Humans
Mammalian orthoreovirus 3
/ genetics
Mice
Mice, Inbred C57BL
Oncolytic Virotherapy
/ methods
Orthoreovirus, Mammalian
/ genetics
Phylogeny
Reoviridae
/ genetics
Viral Proteins
/ metabolism
Virus Replication
/ genetics
divergence
oncolytic
reovirus
strains
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
31 01 2020
31 01 2020
Historique:
received:
01
10
2019
accepted:
12
11
2019
pubmed:
22
11
2019
medline:
22
8
2020
entrez:
22
11
2019
Statut:
epublish
Résumé
Little is known about how genetic variations in viruses affect their success as therapeutic agents. The type 3 Dearing strain of
Identifiants
pubmed: 31748391
pii: JVI.01688-19
doi: 10.1128/JVI.01688-19
pmc: PMC6997766
pii:
doi:
Substances chimiques
Amino Acids
0
Viral Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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