Circular ecDNA promotes accessible chromatin and high oncogene expression.

Cell Line, Tumor Chromatin / chemistry DNA, Circular / genetics Gene Expression Regulation, Neoplastic / genetics Humans Microscopy, Electron, Scanning Neoplasms / genetics Oncogenes / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
11 2019
Historique:
received: 06 11 2018
accepted: 26 09 2019
pubmed: 22 11 2019
medline: 14 4 2020
entrez: 22 11 2019
Statut: ppublish

Résumé

Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in cancer

Identifiants

DOI: 10.1038/s41586-019-1763-5 PMID: 31748743 PMC: PMC7094777
pubmed: 31748743
doi: 10.1038/s41586-019-1763-5
pii: 10.1038/s41586-019-1763-5
pmc: PMC7094777
mid: NIHMS1065820
doi:

Substances chimiques

Chromatin 0
DNA, Circular 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

699-703

Subventions

Organisme : NHGRI NIH HHS
ID : RM1 HG007735
Pays : United States
Organisme : NINDS NIH HHS
ID : P30 NS047101
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS073831
Pays : United States
Organisme : NIH HHS
ID : NS73831
Pays : United States
Organisme : NIH HHS
ID : GM114362
Pays : United States
Organisme : NHGRI NIH HHS
ID : P50 HG007735
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS080939
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA209919
Pays : United States
Organisme : NIH HHS
ID : S10 OD023527
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114362
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM065490
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA067754
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009523
Pays : United States

Références

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Auteurs

Sihan Wu (S)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Kristen M Turner (KM)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Boundless Bio, Inc., La Jolla, CA, USA.

Nam Nguyen (N)

Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.
Boundless Bio, Inc., La Jolla, CA, USA.

Ramya Raviram (R)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Marcella Erb (M)

UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.

Jennifer Santini (J)

UCSD Light Microscopy Core Facility, Department of Neurosciences, University of California at San Diego, La Jolla, CA, USA.

Jens Luebeck (J)

Bioinformatics & Systems Biology Graduate Program, University of California at San Diego, La Jolla, CA, USA.

Utkrisht Rajkumar (U)

Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA.

Yarui Diao (Y)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Department of Cell Biology, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA.
Department of Orthopaedic Surgery, Regeneration Next Initiative, Duke University School of Medicine, Durham, NC, USA.

Bin Li (B)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Wenjing Zhang (W)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Nathan Jameson (N)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

M Ryan Corces (MR)

Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.

Jeffrey M Granja (JM)

Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.

Xingqi Chen (X)

Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA.
Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Ceyda Coruh (C)

Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Armen Abnousi (A)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Jack Houston (J)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Zhen Ye (Z)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Rong Hu (R)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Miao Yu (M)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Hoon Kim (H)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

Julie A Law (JA)

Plant Molecular and Cellular Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.

Roel G W Verhaak (RGW)

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

Ming Hu (M)

Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.

Frank B Furnari (FB)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA.

Howard Y Chang (HY)

Center for Personal Dynamic Regulomes, Stanford University, Stanford, CA, USA. howchang@stanford.edu.
Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA. howchang@stanford.edu.

Bing Ren (B)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu.
Department of Cellular and Molecular Medicine, Center for Epigenomics, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu.
Institute of Genomic Medicine, Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA. biren@ucsd.edu.

Vineet Bafna (V)

Department of Computer Science and Engineering, University of California at San Diego, La Jolla, CA, USA. vbafna@cs.ucsd.edu.

Paul S Mischel (PS)

Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu.
Moores Cancer Center, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu.
Department of Pathology, University of California at San Diego, La Jolla, CA, USA. pmischel@ucsd.edu.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ADN circulaire › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes tumoraux › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Microscopie électronique à balayage › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Tumeurs › Circular ecDNA promotes accessible chromatin...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Circular ecDNA promotes accessible chromatin...