Longitudinal Analysis of Group A Streptococcus emm Types and emm Clusters in a High-Prevalence Setting: Relationship between Past and Future Infections.
Adolescent
Antibodies, Bacterial
/ blood
Antigens, Bacterial
/ immunology
Bacterial Outer Membrane Proteins
/ immunology
Carrier Proteins
/ immunology
Child
Child, Preschool
Female
Fiji
/ epidemiology
Humans
Longitudinal Studies
Male
Skin Diseases, Bacterial
/ epidemiology
Streptococcal Infections
/ epidemiology
Streptococcus pyogenes
/ immunology
Students
Streptococcus pyogenes
emm cluster
immunity
skin infection
Journal
The Journal of infectious diseases
ISSN: 1537-6613
Titre abrégé: J Infect Dis
Pays: United States
ID NLM: 0413675
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
received:
14
05
2019
accepted:
20
11
2019
pubmed:
22
11
2019
medline:
5
2
2021
entrez:
22
11
2019
Statut:
ppublish
Résumé
Group A Streptococcus is a pathogen of global importance, but despite the ubiquity of group A Streptococcus infections, the relationship between infection, colonization, and immunity is still not completely understood. The M protein, encoded by the emm gene, is a major virulence factor and vaccine candidate and forms the basis of a number of classification systems. Longitudinal patterns of emm types collected from 457 Fijian schoolchildren over a 10-month period were analyzed. No evidence of tissue tropism was observed, and there was no apparent selective pressure or constraint of emm types. Patterns of emm type acquisition suggest limited, if any, modification of future infection based on infection history. Where impetigo is the dominant mode of transmission, circulating emm types either may not be constrained by ecological niches or population immunity to the M protein, or they may require several infections over a longer period of time to induce such immunity.
Identifiants
pubmed: 31748786
pii: 5636896
doi: 10.1093/infdis/jiz615
pmc: PMC7137891
doi:
Substances chimiques
Antibodies, Bacterial
0
Antigens, Bacterial
0
Bacterial Outer Membrane Proteins
0
Carrier Proteins
0
streptococcal M protein
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1429-1437Commentaires et corrections
Type : CommentIn
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
Références
Pathology. 2017 Dec;49(7):765-769
pubmed: 29079005
Epidemiol Infect. 2007 Nov;135(8):1398-405
pubmed: 17306049
J Pediatric Infect Dis Soc. 2017 Jun 1;6(2):187-196
pubmed: 28204534
Pediatr Infect Dis. 1985 Jul-Aug;4(4):374-8
pubmed: 3895177
Lancet Infect Dis. 2009 Oct;9(10):611-6
pubmed: 19778763
J Clin Microbiol. 2006 Jun;44(6):2160-6
pubmed: 16757615
Clin Microbiol Infect. 2017 Sep;23(9):677.e1-677.e3
pubmed: 28336383
BMC Infect Dis. 2016 Oct 12;16(1):561
pubmed: 27733129
Microbiol Spectr. 2018 Sep;6(5):
pubmed: 30191802
Vaccine. 2010 Jul 19;28(32):5301-5
pubmed: 20665975
Clin Infect Dis. 2017 Oct 16;65(9):1523-1531
pubmed: 29020160
Expert Rev Vaccines. 2009 Dec;8(12):1705-20
pubmed: 19905872
Curr Opin Infect Dis. 2016 Jun;29(3):295-303
pubmed: 26895573
Pediatr Infect Dis J. 2009 Jun;28(6):477-82
pubmed: 19483515
Pediatrics. 2004 Nov;114(5):1212-9
pubmed: 15520098
PLoS Negl Trop Dis. 2009 Jun 23;3(6):e467
pubmed: 19547749
J Clin Microbiol. 2005 Sep;43(9):4369-76
pubmed: 16145079
J Infect Dis. 2014 Oct 15;210(8):1325-38
pubmed: 24799598
Future Microbiol. 2010 Apr;5(4):623-38
pubmed: 20353302
J Exp Med. 1959 Aug 1;110(2):271-92
pubmed: 13673139
PLoS Pathog. 2016 Dec 27;12(12):e1006122
pubmed: 28027314
Lancet Infect Dis. 2005 Nov;5(11):685-94
pubmed: 16253886
PLoS One. 2006 Dec 20;1:e10
pubmed: 17183632
N Engl J Med. 1970 Jan 8;282(2):78-85
pubmed: 4901868