Insulin Signaling in Bone Marrow Adipocytes.

Adipocytes / metabolism Adipogenesis Adipose Tissue / metabolism Animals Bone Diseases, Metabolic / metabolism Bone Marrow / metabolism Bone Marrow Cells / metabolism Bone and Bones / metabolism Cell Differentiation Cellular Senescence Glucagon-Like Peptide 1 / metabolism Glucose / metabolism Humans Insulin / metabolism Insulin Receptor Substrate Proteins / metabolism Insulin Resistance Insulin-Like Growth Factor Binding Protein 4 / metabolism Insulin-Like Growth Factor I / metabolism Mesenchymal Stem Cells / metabolism Obesity / metabolism Parathyroid Hormone / metabolism Receptor for Advanced Glycation End Products / metabolism Receptor, Insulin / metabolism
Bone marrow adipose tissue Bone marrow mesenchymal stem cells Insulin signaling Marrow adiposity

Journal

Current osteoporosis reports
ISSN: 1544-2241
Titre abrégé: Curr Osteoporos Rep
Pays: United States
ID NLM: 101176492

Informations de publication

Date de publication:
12 2019
Historique:
pubmed: 22 11 2019
medline: 21 10 2020
entrez: 22 11 2019
Statut: ppublish

Résumé

The goal of this review is to discuss the role of insulin signaling in bone marrow adipocyte formation, metabolic function, and its contribution to cellular senescence in relation to metabolic bone diseases. Insulin signaling is an evolutionally conserved signaling pathway that plays a critical role in the regulation of metabolism and longevity. Bone is an insulin-responsive organ that plays a role in whole body energy metabolism. Metabolic disturbances associated with obesity and type 2 diabetes increase a risk of fragility fractures along with increased bone marrow adiposity. In obesity, there is impaired insulin signaling in peripheral tissues leading to insulin resistance. However, insulin signaling is maintained in bone marrow microenvironment leading to hypermetabolic state of bone marrow stromal (skeletal) stem cells associated with accelerated senescence and accumulation of bone marrow adipocytes in obesity. This review summarizes current findings on insulin signaling in bone marrow adipocytes and bone marrow stromal (skeletal) stem cells and its importance for bone and fat metabolism. Moreover, it points out to the existence of differences between bone marrow and peripheral fat metabolism which may be relevant for developing therapeutic strategies for treatment of metabolic bone diseases.

Identifiants

DOI: 10.1007/s11914-019-00552-8 PMID: 31749085 PMC: PMC6944646
pubmed: 31749085
doi: 10.1007/s11914-019-00552-8
pii: 10.1007/s11914-019-00552-8
pmc: PMC6944646
doi:

Substances chimiques

Insulin 0
Insulin Receptor Substrate Proteins 0
Insulin-Like Growth Factor Binding Protein 4 0
Parathyroid Hormone 0
Receptor for Advanced Glycation End Products 0
Insulin-Like Growth Factor I 67763-96-6
Glucagon-Like Peptide 1 89750-14-1
Receptor, Insulin EC 2.7.10.1
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

446-454

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Auteurs

Michaela Tencerova (M)

Department of Molecular Endocrinology, KMEB, University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark. mtencerova@health.sdu.dk.
Department of Molecular Physiology of Bone, Institute of Physiology, Czech Academy of Sciences, 142 20, Prague 4, Czech Republic. mtencerova@health.sdu.dk.

Meshail Okla (M)

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Moustapha Kassem (M)

Department of Molecular Endocrinology, KMEB, University of Southern Denmark and Odense University Hospital, 5000, Odense C, Denmark.
Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Cellular and Molecular Medicine, The Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), Panum Institute, University of Copenhagen, Copenhagen, Denmark.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adipogenèse › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Maladies osseuses métaboliques › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Hormones gastrointestinales › Peptides glucagon-like › Glucagon-like peptide 1 › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Substrats du récepteur à l'insuline › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Protéines de liaison aux IGF › Protéine-4 de liaison aux IGF › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Somatomédines › Facteur de croissance IGF-I › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches multipotentes › Cellules souches mésenchymateuses › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormone parathyroïdienne › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Facteurs biologiques › Médiateurs de l'inflammation › Récepteur spécifique des produits finaux de glycosylation avancée › Insulin Signaling in Bone Marrow Adipocytes.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone pancréatique › Récepteur à l'insuline › Insulin Signaling in Bone Marrow Adipocytes.