Inositols' Importance in the Improvement of the Endocrine-Metabolic Profile in PCOS.
androgen excess
d-chiro-inositol
metabolic diseases
myo-inositol
ovulation problems
polycystic ovary syndrome
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Nov 2019
18 Nov 2019
Historique:
received:
03
10
2019
revised:
13
11
2019
accepted:
14
11
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility and metabolic problems among women of reproductive age. The mechanism of PCOS is associated with concurrent alterations at the hormonal level. The diagnosis assumes the occurrence of three interrelated symptoms of varying severity, namely ovulation disorders, androgen excess, or polycystic ovarian morphology (PCOM), which all require a proper therapeutic approach. The main symptom seems to be an increased androgen concentration, which in turn may contribute to different metabolic disorders. A number of papers have demonstrated the significant role of inositol therapy in PCOS. However, there is a lack of detailed discussion about the importance of myo-inositol (MI) and d-chiro-inositol (DCI) in reference to particular symptoms. Thus, the aim of this review is to present the effectiveness of MI and DCI treatment for PCOS symptoms. Moreover, the review is focused on analyzing the use of inositols, taking into account their physiological properties, together with the mechanism of individual PCOS symptom formation.
Identifiants
pubmed: 31752081
pii: ijms20225787
doi: 10.3390/ijms20225787
pmc: PMC6888190
pii:
doi:
Substances chimiques
Vitamin B Complex
12001-76-2
Inositol
4L6452S749
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : BIOSTRATEG
ID : BIOSTRATEG2/298205/9/NCBR/2016
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