MiRNAs as Players in Rhabdomyosarcoma Development.
microRNA
pediatric tumors
rhabdomyosarcoma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Nov 2019
19 Nov 2019
Historique:
received:
30
10
2019
revised:
15
11
2019
accepted:
18
11
2019
entrez:
23
11
2019
pubmed:
23
11
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, generally, responsive to the modern multimodal therapeutic approaches, the prognosis of RMS depends on multiple variables and for some patients the outcome remains dismal. Further comprehension of the molecular and cellular biology of RMS would lead to identification of novel therapeutic targets. MicroRNAs (miRNAs) are small non-coding RNAs proved to function as key regulators of skeletal muscle cell fate determination and to play important roles in RMS pathogenesis. The purpose of this review is to better delineate the role of miRNAs as a biomarkers or functional leaders in RMS development, so to possibly elucidate some of RMS molecular mechanisms and potentially therapeutically target them to improve clinical management of pediatric RMS.
Identifiants
pubmed: 31752446
pii: ijms20225818
doi: 10.3390/ijms20225818
pmc: PMC6888285
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
RNA, Small Untranslated
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Associazione Bianca Garavaglia
ID : ABG. A/15/01N; ABG A/18/01A
Organisme : Cariplo Foundation Young Investigator Grant
ID : 2015 n.2015-0901
Organisme : Bando per la valorizzazione della ricerca istituzionale 2016-2017
ID : D/15/1D4
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